Artemisinin is a chemical compound contained in the plant named Artemisia annua, (Wormwood, Sweet annie, Sweet sagewort) that grows in the continental climate, mostly used as antimalarial medicine. Artemisinin derivatives include dihydroartemisinin, artesunate and artemether.
Cancer cells require and uptake a large amount of iron to proliferate. They are more susceptible to the cytotoxic effect of artemisinin than normal cells.
Artemisinin reacts with iron in the cell to form free radicals which than kills the cell it contains.
RESEARCHES:
- Use of artemisinin and its derivatives to treat HPV-infected/transformed cells and cervical cancer: a review
Artemisinin / Uterus-Cervix / (In Vitro, In Vivo, Clinical Basic) - p8 attenuates the apoptosis induced by dihydroartemisinin in cancer cells through promoting autophagy
Artemisinin / Colon, Uterus-Cervix / (In Vitro, In Vivo, Chemo, Synergy) - Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines
Artemisinin / Neuro / (In Vitro) - Additive Cytotoxic Effects of Dihydroartemisinin and Sodium Salicylate on Cancer Cells
Artemisinin / Leukaemia / (In Vitro) - Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs
Artemisinin / Leukaemia / (In Vitro, In Vivo, Chemo, Synergy) - Artesunate in the treatment of metastatic uveal melanoma – First experiences
Artemisinin / Melanoma / (Clinical Basic, Chemo, Synergy) - Mn (II) mediated degradation of artemisinin based on Fe3O4@MnSiO3-FA nanospheres for cancer therapy in vivo
Artemisinin / Lung / (In Vivo) - Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: A randomized controlled trial
Artemisinin / Lung / (Clinical Basic, Chemo) - Artemisinin induces A549 cell apoptosis dominantly via a reactive oxygen species-mediated amplification activation loop among caspase-9, -8 and -3
Artemisinin / Lung / (In Vitro) - Inhibition of autophagy by chloroquine potentiates synergistically anti-cancer property of artemisinin by promoting ROS dependent apoptosis
Artemisinin / Lung / (In Vitro) - Dihydroarteminsin-Induced Apoptosis is not Dependent on the Translocation of Bim to the Endoplasmic Reticulum in Human Lung Adenocarcinoma Cells
Artemisinin / Lung / (In Vitro) - Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells
Artemisinin / Lung / (In Vitro) - DHA regulates angiogenesis and improves the efficiency of CDDP for the treatment of lung carcinoma
Artemisinin / Lung / (In Vitro, In Vivo, Chemo, Synergy) - Enhanced apoptotic effects of dihydroartemisinin-aggregated gelatin and hyaluronan nanoparticles on human lung cancer cells
Artemisinin / Lung / (In Vitro) - A survey on anticancer effects of artemisinin, iron, miconazole, and butyric acid on 5637 (bladder cancer) and 4T1 (Breast cancer) cell lines
Artemisinin / Breast, Bladder / (In Vitro) - Artesunate Induces Apoptosis of Bladder Cancer Cells by miR-16 Regulation of COX-2 Expression
Artemisinin / Bladder / (In Vitro, In Vivo) - Synergic effects of artemisinin and resveratrol in cancer cells
Artemisinin, Resveratrol / Liver, Uterus-Cervix / (In Vitro, Synergy) - Artemisinin Represses Telomerase Subunits and Induces Apoptosis in HPV-39 Infected Human Cervical Cancer Cells
Artemisinin / Uterus-Cervix / (In Vitro) - Enhancement of cytotoxicity of artemisinin toward cancer cells by transferrin-mediated carbon nanotubes nanoparticles
Artemisinin / Breast / (In Vitro, In Vivo) - Dihydroartemisinin induces apoptosis of cervical cancer cells via upregulation of RKIP and downregulation of bcl-2
Artemisinin / Uterus-Cervix / (In Vitro, In Vivo) - Cytotoxic Effect of Artemisinin and Its Derivatives on Human Osteosarcoma Cell Lines
Artemisinin / Bone-Cartilage / (In Vitro) - Influence of Artemisia annua extract derivatives on Proliferation, apoptosis and metastasis of osteosarcoma cells
Artemisinin / Bone-Cartilage / (In Vitro) - Artemisinin and Curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity
Artemisinin, Curcumin / Brain / (In Vivo) - Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma
Artemisinin / Neuro / (In Vitro, In Vivo) - On the preparation of transferrin modified artesunate nanoliposomes and their glioma-targeting treatment in-vitro and in-vivo
Artemisinin / Brain / (In Vitro, In Vivo) - Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling
Artemisinin / Neuro / (In Vitro) - Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3
Artemisinin / Brain, Stem_Cell / (In Vitro) - Artesunate Enhances the Antiproliferative Effect of Temozolomide on U87MG and A172 Glioblastoma Cell Lines
Artemisinin / Brain / (In Vitro, Chemo, Synergy) - Dihydroartemisinin inhibits the mammalian target of rapamycin-mediated signaling pathways in tumor cells
Artemisinin / Prostate, Lymphoma, Leukaemia, Myeloma, Uterus-Cervix, Brain, Bone-Cartilage / (In Vitro) - Growth inhibitory effect of dihydroartemisinin on Bcr/Abl+ chronic myeloid leukemia K562 cells involve AKT, ERK and NF-κB modulation
Artemisinin / Leukaemia / (In Vitro) - Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells
Artemisinin / Lung, Breast, Prostate, Melanoma, Leukaemia, Kidney, Ovarian, Neuro / (In Vitro) - Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity
Artemisinin / Leukaemia / (In Vitro) - Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis
Artemisinin / Myeloma / (In Vitro) - Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo
Artemisinin / Gastric / (In Vitro, In Vivo) - Dihydroartemisinin Accentuates the Anti-Tumor Effects of Photodynamic Therapy via Inactivation of NF-κB in Eca109 and Ec9706 Esophageal Cancer Cells
Artemisinin / Gastric / (In Vitro) - In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells
Artemisinin / Melanoma / (In Vitro) - Differential Effect of Artemisinin Against Cancer Cell Lines
Artemisinin / Myeloma / (In Vivo) - Enhanced delivery of artemisinin and its analogues to cancer cells by their adducts with human serum transferrin
Artemisinin / Liver / (In Vitro) - Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action
Artemisinin / Liver / (In Vitro, In Vivo) - Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo
Artemisinin / Liver / (In Vitro, In Vivo) - Dihydroartemisinin induces endoplasmic reticulum stress-mediated apoptosis in HepG2 human hepatoma cells
Artemisinin / Liver / (In Vitro) - Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells
Artemisinin / Liver / (In Vitro, In Vivo) - Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway
Artemisinin / Colon / (In Vitro) - A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer
Artemisinin / Colon / (Clinical Full) - Dihydroartemisinin Enhances Apo2L/TRAIL-Mediated Apoptosis in Pancreatic Cancer Cells via ROS-Mediated Up-Regulation of Death Receptor 5
Artemisinin / Pancreatic / (In Vitro) - The activation of c-Jun NH2-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells
Artemisinin / Pancreatic / (In Vitro) - Anticancer Effect of Dihydroartemisinin (DHA) in a Pancreatic Tumor Model Evaluated by Conventional Methods and Optical Imaging
Artemisinin / Pancreatic / (In Vitro, In Vivo) - Artemisinin triggers a G1 cell cycle arrest of human Ishikawa endometrial cancer cells and inhibits Cyclin Dependent Kinase-4 promoter activity and expression by disrupting NF-kB transcriptional signaling
Artemisinin / Uterus-Cervix / (In Vitro) - Artemisinin inhibits gastric cancer cell proliferation through upregulation of p53
Artemisinin / Gastric / (In Vitro) - Anti-cancer activity of DHA on gastric cancer—an in vitro and in vivo study
Artemisinin / Gastric / (In Vitro, In Vivo) - Artesunate inhibits the growth of gastric cancer cells through the mechanism of promoting oncosis both in vitro and in vivo
Artemisinin / Gastric / (In Vitro, In Vivo) - Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2
Artemisinin / Gastric / (In Vitro) - Apoptosis of nasopharyngeal carcinoma cells line CNE-2 induced by dihydroartemisinin and its possible mechanism
Artemisinin / Head_&_Neck / (In Vitro) - Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells
Artemisinin / Head_&_Neck / (In Vitro) - Activity of Novel Plant Extracts Against Medullary Thyroid Carcinoma Cells
Artemisinin / Thyroidal / (In Vitro) - Modeling and prediction of cytotoxicity of artemisinin for treatment of the breast cancer by using artificial neural networks
Artemisinin / Breast / (In Vitro) - pH-Responsive Artemisinin Derivatives and Lipid Nanoparticle Formulations Inhibit Growth of Breast Cancer Cells In Vitro and Induce Down-Regulation of HER Family Members
Artemisinin / Breast / (In Vivo) - Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells
Artemisinin / Breast / (In Vitro) - Artemisinin-Transferrin Conjugate Retards Growth of Breast Tumors in the Rat
Artemisinin / Breast / (In Vivo) - Effects of Artemisinin Dimers on Rat Breast Cancer Cells In Vitro and In Vivo
Artemisinin / Breast / (In Vitro, In Vivo) - Experimental treatment of breast cancer-bearing BALB/c mice by artemisinin and transferrin-loaded magnetic nanoliposomes
Artemisinin / Breast / (In Vivo) - Dihydroartemisinin Exerts Its Anticancer Activity through Depleting Cellular Iron via Transferrin Receptor-1
Artemisinin / Breast / (In Vitro) - In vitro and in vivo studies of artemisin endoperoxides
Artemisinin / Lung, Breast, Prostate, Melanoma, Leukaemia, Pancreatic, Brain / (In Vitro, In Vivo) - Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71
Artemisinin / Eye_Cavity / (In Vitro) - Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo
Artemisinin / Bone-Cartilage / (In Vitro, In Vivo) - Artesunate induces ROS- and p38 MAPK-mediated apoptosis and counteracts tumor growth in vivo in embryonal rhabdomyosarcoma cells
Artemisinin / Bone-Cartilage / (In Vivo) - Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression
Artemisinin / Prostate / (In Vitro) - Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer
Artemisinin / Ovarian / (In Vitro, In Vivo) - The Antimalaria Agent Artemisinin Exerts Antiangiogenic Effects in Mouse Embryonic Stem Cell-Derived Embryoid Bodies
Artemisinin / Stem_Cell / (In Vitro) - Artemisinin reduces human melanoma cell migration by down-regulating αVβ3 integrin and reducing metalloproteinase 2 production
Artemisinin / Melanoma / (In Vitro) - In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells
Artemisinin / Melanoma / (In Vitro) - The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis
Artemisinin / Melanoma / (In Vitro) - Effect of artesunate on immune cells in ret-transgenic mouse melanoma model
Artemisinin / Melanoma / (In Vivo) - Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells
Artemisinin / Lung / (In Vitro) - First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases
Artemisinin / Lung / (In Vivo) - Dihydroartemisinin induces apoptosis in skin cancer cell line A-431 via ROS pathway
Artemisinin / Skin / (In Vitro) - Dihydroartemisinin suppresses growth of squamous cell carcinoma A431 cells by targeting the Wnt/β-catenin pathway
Artemisinin / Skin / (In Vitro) - Inhibition of angiogenesis in vivo and growth of Kaposi\’s sarcoma xenograft tumors by the anti-malarial artesunate
Artemisinin / Skin / (In Vivo) - Artemisinin Represses Telomerase Subunits and Induces Apoptosis in HPV-39 Infected Human Cervical Cancer Cells
Artemisinin / Uterus-Cervix / (In Vitro) - Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo
Artemisinin / Uterus-Cervix / (In Vitro, In Vivo) - Interferon-α enhances artemisinin-induced differentiation of HL-60 leukemia cells via a PKCα/ERK pathway
Artemisinin / Leukaemia / (In Vitro) - Artemisinin Induces Apoptosis in Human Cancer Cells
Artemisinin / Leukaemia / (In Vitro) - Synergic effects of artemisinin and resveratrol in cancer cells
Artemisinin, Resveratrol / Liver, Uterus-Cervix / (In Vitro, Synergy) - Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis
Artemisinin / Gallbladder / (In Vitro, In Vivo) - Artemisinin: an alternative treatment for oral cancer
Artemisinin / Oral / (In Vitro) - Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells
Artemisinin / Oral / (In Vitro) - Artemisinin: An Alternative Treatment for Oral Squamous Cell Carcinoma
Artemisinin / Oral / (In Vitro) - Artemisinin Inhibits Tumor Lymphangiogenesis by Suppression of Vascular Endothelial Growth Factor C
Artemisinin / Lymphoma / (In Vitro) - LyP-1 Modification To Enhance Delivery of Artemisinin or Fluorescent Probe Loaded Polymeric Micelles to Highly Metastatic Tumor and Its Lymphatics
Artemisinin / Lymphoma / (In Vitro, In Vivo) - Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis
Artemisinin / Kidney / (In Vitro, In Vivo) - Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells
Artemisinin / Head_&_Neck / (In Vitro) - Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells
Artemisinin / Head_&_Neck / (In Vitro) - Down-regulation of BMI-1 cooperates with artemisinin on growth inhibition of nasopharyngeal carcinoma cells
Artemisinin / Head_&_Neck / (In Vitro) - Artesunate inhibits the growth of gastric cancer cells through the mechanism of promoting oncosis both in vitro and in vivo
Artemisinin / Gastric / (In Vitro, In Vivo) - Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro
Artemisinin / Stem_Cell / (In Vitro) - Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo
Artemisinin / Stem_Cell / (In Vitro, In Vivo, Chemo, Synergy) - In vivo study of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice
Artemisinin / Liver / (In Vivo) - Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice
Artemisinin / Liver / (In Vivo) - Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells
Artemisinin / Breast / (In Vitro) - Artemisinin triggers a G1 cell cycle arrest of human Ishikawa endometrial cancer cells and inhibits cyclin-dependent kinase-4 promoter activity and expression by disrupting nuclear factor-κB transcriptional signalin
Artemisinin / Uterus-Cervix / (In Vitro) - A preliminary study on combination therapy of artemisinin dimer oxime and topotecan against nonsmall cell lung cancer in mice
Artemisinin / Lung / (In Vivo, Chemo, Synergy) - Synthesis of Artemisinin–Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer
Artemisinin / Breast, Uterus-Cervix / (In Vitro) - The selectivity of artemisinin-based drugs on human lung normal and cancer cells
Artemisinin / Lung / (In Vitro) - Dried leaf artemisia annua efficacy against non-small cell lung cancer
Artemisinin / Lung / (In Vitro, In Vivo) - Arsenic trioxide and artemisinin act synergistically to kill tumor cells in vitro.
Artemisinin / Lung, Liver, Uterus-Cervix / (In Vitro, Chemo, Synergy) - Artesunate enhances radiosensitivity of esophageal cancer cells by inhibiting the repair of DNA damage
Artemisinin / Gastric / (In Vitro, Chemo, Synergy) - Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro
Artemisinin / Brain / (In Vitro, In Vivo) - Dihydroartemisinin induces apoptosis and inhibits proliferation, migration, and invasion in epithelial ovarian cancer via inhibition of the hedgehog signaling pathway
Artemisinin / Ovarian / (In Vitro) - Thermal degradation, kinetic analysis and evaluation of biological activity on human melanoma for artemisinin
Artemisinin / Melanoma / (In Vitro) - Dihydroartemisinin potentiates antitumor activity of 5-fluorouracil against a resistant colorectal cancer cell line
Artemisinin / Colon / (In Vitro, Chemo, Synergy) - Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling
Artemisinin / Colon / (In Vitro) - Malaria and Burkitt\’s lymphoma an in silico analysis of gene expression links between malaria and burkitt\’s lymphoma and potential anticancer activity of Artemisinin derivatives
Artemisinin / Lymphoma / (In Vitro) - Antimalarial Dihydroartemisinin triggers autophagy within HeLa cells of human cervical cancer through Bcl-2 phosphorylation at Ser70
Artemisinin / Ovarian / (In Vitro) - In vitro assessment of cytotoxic, genotoxic and mutagenic effects of antimalarial drugs artemisinin and artemether in human lymphocytes
Artemisinin / Leukaemia / (In Vitro) - Dihydroartemisinin inhibits colon cancer cell viability by inducing apoptosis through up-regulation of PPARγ expression
Artemisinin / Colon / (In Vitro) - Dihydroartemisinin increases gemcitabine therapeutic efficacy in ovarian cancer by inducing reactive oxygen species
Artemisinin / Ovarian / (In Vitro, In Vivo, Chemo, Synergy) - Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo
Artemisinin / Breast / (In Vitro, In Vivo) - Transferrin receptor-dependent cytotoxicity of artemisinin–transferrin conjugates on prostate cancer cells and induction of apoptosis
Artemisinin / Prostate / (In Vitro) - Synergistic Cytotoxicity of Artemisinin and Sodium Butyrate on Human Cancer Cells
Artemisinin / Leukaemia / (In Vitro, Synergy) - Novel multifunctional nanocarrier-mediated codelivery for targeting and treatment of prostate cancer
Artemisinin / Prostate / (In Vitro, Chemo, Synergy)