Garcinol is extracted from the rind of the fruit of Garcinia indica, a plant found extensively in tropical regions.
There is ample data to suggest potent antioxidant properties of this compound which have been used to explain most of its observed biological activities
Although the fruit has been consumed traditionally over centuries, its biological activities, specifically its anticancer potential is a result of recent scientific investigations.
RESEARCHES:
- Potential Role of Garcinol as an Anticancer Agent
Garcinol / Breast, Colon, Leukaemia, Pancreatic / (In Vitro, In Vivo) - Antitumor Activity of Garcinol in Human Prostate Cancer Cells and Xenograft Mice
Garcinol / Prostate / (In Vivo) - Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
Garcinol / Liver / (In Vitro, In Vivo) - Targeted inhibition of STAT3 dimerization by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
Garcinol / Liver / (In Vitro, In Vivo) - Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis
Garcinol / Liver / (In Vitro) - Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells
Garcinol / Pancreatic, Stem_Cell / (In Vitro) - Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures
Garcinol / Pancreatic / (In Vitro, Chemo, Synergy) - Garcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells
Garcinol / Pancreatic, Stem_Cell / (In Vitro) - Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
Garcinol / Pancreatic / (In Vivo) - Effect Of Garcinol On Change In Gene Expression In Pancreatic Cancer Mouse Model
Garcinol / Pancreatic / (In Vivo) - Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
Garcinol / Breast / (In Vitro, In Vivo) - Anticancer action of garcinol in vitro and in vivo is mediated through inhibition of STAT-3 signaling
Garcinol / Breast, Prostate, Pancreatic / (In Vitro, In Vivo) - Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/â-catenin /STAT3 axis signalling pathway in human non-small cell lung carcinomas
Garcinol / Lung, Stem_Cell / (In Vitro) - Induction of p21Waf1/Cip1 by Garcinol via Downregulation of p38-MAPK Signaling in p53-Independent H1299 Lung Cancer
Garcinol / Lung / (In Vitro) - Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol
Garcinol / Lung / (In Vitro) - Induction of Apoptosis by Garcinol and Curcumin through Cytochrome c Release and Activation of Caspases in Human Leukemia HL-60 Cells
Garcinol / Leukaemia / (In Vitro) - Cytotoxic Benzophenone Derivatives from Garcinia Species Display a Strong Apoptosis-Inducing Effect against Human Leukemia Cell Lines
Garcinol / Leukaemia / (In Vitro) - The Molecular Targets of Garcinol Confer Antitumor Effects
Garcinol / Leukaemia / (In Vitro, In Vivo) - Anticancer Activity of Garcinia morella on T-Cell Murine Lymphoma Via Apoptotic Induction
Garcinol / Lymphoma / (In Vitro, In Vivo) - Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats
Garcinol / Colon / (In Vivo) - Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
Garcinol / Colon / (In Vitro) - Garcinol suppresses inflammation-associated colon carcinogenesis in mice
Garcinol / Colon / (In Vivo) - Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
Garcinol / Oral / (In Vitro) - Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats
Garcinol / Oral / (In Vivo) - Chemical studies on antioxidant mechanism of garcinol: analysis of radical reaction products of garcinol and their antitumor activities
Garcinol / Uterus-Cervix / (In Vitro) - Inhibitory effect of garcinol against 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice
Garcinol / Skin / (In Vivo) - Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma
Garcinol / Head_&_Neck / (In Vitro, In Vivo) - Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats
Garcinol / Colon / (In Vivo) - Polyisoprenylated Benzophenone, Garcinol, a Natural Histone Acetyltransferase Inhibitor, Represses Chromatin Transcription and Alters Global Gene Expression*
Garcinol / Uterus-Cervix / (In Vitro, In Vivo) - Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies
Garcinol / Melanoma / (In Vitro, In Vivo) - Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
Garcinol / Colon / (In Vitro) - Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling
Garcinol / Breast, Prostate / (In Vitro, In Vivo) - Antitumor Activity of Garcinol in Human Prostate Cancer Cells and Xenograft Mice
Garcinol / Prostate / (In Vitro, In Vivo) - Stimulation of Suicidal Erythrocyte Death by Garcinol
Garcinol / Leukaemia / (In Vitro) - Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins
Garcinol / Breast / (In Vitro, In Vivo) - Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
Garcinol / Breast, Prostate, Colon, Leukaemia, Kidney, Gastric, Myeloma / (In Vitro) - Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- KappaB signaling Aamir Ahmad1, Zhiwei
Garcinol / Prostate, Pancreatic / (In Vitro) - Antitumor Activity of Garcinol in Human Prostate Cancer Cells and Xenograft Mice.
Garcinol / Prostate / (In Vitro, In Vivo) - Effect Of Garcinol On Change In Gene Expression In Pancreatic Cancer Mouse Model
Garcinol / Pancreatic / (In Vitro, In Vivo) - Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
Garcinol / Head_&_Neck / (In Vitro, In Vivo, Chemo, Synergy) - Garcinol, an Acetyltransferase Inhibitor, Suppresses Proliferation of Breast Cancer Cell Line MCF-7 Promoted by 17β-Estradiol
Garcinol / Breast / (In Vitro) - Apoptosis-inducing effect of garcinol is mediated by NF-κB signaling in breast cancer cells
Garcinol / Breast / (In Vitro) - Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
Garcinol / Breast / (In Vitro) - Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects
Garcinol / Colon / (In Vitro) - Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
Garcinol / Colon / (In Vitro) - Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
Garcinol / Colon / (In Vitro) - Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation
Garcinol / Lung / (In Vitro, In Vivo) - Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining
Garcinol / Lung, Uterus-Cervix / (In Vitro, Chemo, Synergy) - Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives
Garcinol / Colon / (In Vitro) - Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
Garcinol / Pancreatic / (In Vivo) - Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model
Garcinol / Breast / (In Vitro, In Vivo) - The complement regulator compact disc46 is a costimulatory molecule for humanthe complement regulator compact disc46 is a costimulatory molecule for human
Garcinol / Brain / (In Vitro, In Vivo, Chemo, Synergy) - Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
Garcinol / Lung, Kidney, Liver / (In Vitro, Chemo, Synergy) - Garcinol exerts anti-cancer effect in human cervical cancer cells through upregulation of T-cadherin
Garcinol / Uterus-Cervix / (In Vitro) - Dietary Garcinol Arrests Pancreatic Cancer in p53 and K-ras Conditional Mutant Mouse Model
Garcinol / Pancreatic / (In Vivo) - Pharmacologic inhibition of STAT5 in acute myeloid leukemia
Garcinol / Leukaemia / (In Vitro, Chemo, Synergy) - Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/β-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas
Garcinol / Lung, Stem_Cell / (In Vitro, In Vivo) - Anti-proliferative and anti-invasive effects of garcinol from Garcinia indica on gallbladder carcinoma cells
Garcinol / Gallbladder / (In Vitro) - Opposite Effects of Garcinol on Tumor Energy Metabolism in Oral Squamous Cell Carcinoma Cells
Garcinol / Oral / (In Vitro) - Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAs
Garcinol / Lung / (In Vitro, Chemo, Synergy) - Emerging Role of Garcinol in Targeting Cancer Stem Cells of Non-small Cell Lung Cancer
Garcinol / Lung, Stem_Cell / (In Vitro)