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Research Base – Cancer – Thymoquinonethe admin2020-10-02T10:28:05-01:00Thymoquinone is an anticancer phytochemical commonly found in black cumin.
Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation.
Here is the list of scientific papers that explored its anticancer properties and actions:
RESEARCHES:
- Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo
Thymoquinone / Breast / (In Vitro, In Vivo) - Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
Thymoquinone / Skin / (In Vitro) - Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma
Thymoquinone / Skin / (In Vitro, In Vivo) - The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo
Thymoquinone / Head_&_Neck, Bone-Cartilage / (In Vitro, In Vivo) - Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo
Thymoquinone / Gallbladder / (In Vitro, In Vivo) - Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53
Thymoquinone / Breast / (In Vitro) - Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway
Thymoquinone / Lung / (In Vitro) - Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo
Thymoquinone / Lung / (In Vitro, In Vivo) - Evaluation of the protective effect of Nigella sativa extract and its primary active component thymoquinone against DMBA-induced breast cancer in female rats
Thymoquinone / Breast / (In Vivo) - Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
Thymoquinone / Breast / (In Vitro) - Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells
Thymoquinone / Breast / (In Vitro) - Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
Thymoquinone / Breast / (In Vitro) - Thymoquinone inhibits microtubule polymerization by tubulin binding and causes mitotic arrest following apoptosis in A549 cells
Thymoquinone / Lung / (In Vitro) - Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells
Thymoquinone / Breast / (In Vitro) - Cellular responses with thymoquinone treatment in human breast cancer cell line MCF-7
Thymoquinone / Breast / (In Vitro) - Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
Thymoquinone / Breast / (In Vivo) - The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer
Thymoquinone / Breast / (In Vitro, Chemo, Synergy) - Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
Thymoquinone / Leukaemia / (In Vitro) - Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro
Thymoquinone / Leukaemia / (In Vitro) - Thymoquinone induces apoptosis in malignant T-cells via generation of ROS
Thymoquinone / Leukaemia / (In Vitro) - Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In Vitro
Thymoquinone / Leukaemia / (In Vivo) - Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1
Thymoquinone / Leukaemia / (In Vitro) - The effects of thymoquinone and Doxorubicin on leukemia and cardiomyocyte cell lines
Thymoquinone / Leukaemia / (In Vitro) - Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
Thymoquinone / Myeloma / (In Vivo, Chemo, Synergy) - Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
Thymoquinone / Myeloma / (In Vitro) - Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression
Thymoquinone / Myeloma / (In Vitro) - Thymoquinone Inhibits the CXCL12-Induced Chemotaxis of Multiple Myeloma Cells and Increases Their Susceptibility to Fas-Mediated Apoptosis
Thymoquinone / Myeloma / (In Vitro) - Apoptotic Activities of Thymoquinone, an Active Ingredient of Black Seed (Nigella sativa), in Cervical Cancer Cell Lines
Thymoquinone / Uterus-Cervix / (In Vitro) - Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein
Thymoquinone / Uterus-Cervix / (In Vitro) - Effects of (-)epigallocatechin gallate and thymoquinone on proliferation of a PANC-1 cell line in culture
Thymoquinone, EGCG / Pancreatic / (In Vitro) - Synergistic Combination of Gemcitabine and Dietary Molecule Induces Apoptosis in Pancreatic Cancer Cells and Down Regulates PKM2 Expression
Thymoquinone / Pancreatic / (In Vitro, Chemo, Synergy) - Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer
Thymoquinone / Pancreatic / (In Vitro, In Vivo, Chemo, Synergy) - Synthesis, characterization and anti-tumor activity of novel thymoquinone analogs against pancreatic cancer
Thymoquinone / Pancreatic / (In Vitro, Chemo, Synergy) - Effects of Thymoquinone in the Expression of Mucin 4 in Pancreatic Cancer Cells: Implications for the Development of Novel Cancer Therapies
Thymoquinone / Pancreatic / (In Vitro) - Anti-metastasis effect of thymoquinone on human pancreatic cancer.
Thymoquinone / Pancreatic / (In Vitro, In Vivo) - Inhibitory effects of thymoquinone on human pancreatic carcinoma orthotopically implanted in nude mice
Thymoquinone / Pancreatic / (In Vivo) - Inhibition of epithelial-mesenchymal transition in bladder cancer cells via modulation of mTOR signalling
Thymoquinone / Bladder / (In Vitro) - Role of NF-κB in the anti-tumor effect of thymoquinone on bladder cancer
Thymoquinone / Bladder / (In Vitro, In Vivo) - Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma
Thymoquinone / Liver / (In Vivo) - Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis
Thymoquinone / Liver / (In Vitro) - TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
Thymoquinone / Liver / (In Vitro, In Vivo) - Thymoquinone Attenuates Diethylnitrosamine Induction of Hepatic Carcinogenesis Through Antioxidant Signaling
Thymoquinone / Liver / (In Vivo) - Thymoquinone Anticancer Discovery: Possible Mechanisms
Thymoquinone / Breast, Colon, Leukaemia, Liver, Gastric / (In Vitro, In Vivo) - Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo
Thymoquinone / Gastric / (In Vitro, In Vivo) - Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
Thymoquinone / Gastric / (In Vitro, In Vivo) - Thymoquinone Inhibits Autophagy and Induces Cathepsin-Mediated, Caspase-Independent Cell Death in Glioblastoma Cells
Thymoquinone / Brain / (In Vitro) - Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-κB signaling and IL-8 expression
Thymoquinone / Brain / (In Vitro) - Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP
Thymoquinone / Neuro / (In Vitro) - Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
Thymoquinone / Brain / (In Vitro) - Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts
Thymoquinone / Leukaemia, Brain / (In Vitro) - Sialidase NEU4 is involved in glioblastoma stem cell survival
Thymoquinone / Brain, Stem_Cell / (In Vitro) - Thymoquinone Induces Apoptosis in Oral Cancer Cells Through P38β Inhibition
Thymoquinone / Oral / (In Vitro) - Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome
Thymoquinone / Melanoma / (In Vitro) - Phosphorylated IκBα Predicts Poor Prognosis in Activated B-Cell Lymphoma and Its Inhibition with Thymoquinone Induces Apoptosis via ROS Release
Thymoquinone / Lymphoma / (In Vitro) - Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
Thymoquinone / Lymphoma / (In Vitro) - Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway
Thymoquinone / Bone-Cartilage / (In Vitro, In Vivo) - Effects of thymoquinone and selenium on the proliferation of MG 63 cells in tissue culture
Thymoquinone, Selenium / Bone-Cartilage / (In Vitro) - Thymoquinone rich fraction from Nigella sativa and thymoquinone are cytotoxic towards colon and leukemic carcinoma cell lines
Thymoquinone / Colon, Leukaemia / (In Vitro) - Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species
Thymoquinone / Prostate / (In Vitro) - Androgen Receptor– and E2F-1–Targeted Thymoquinone Therapy for Hormone-Refractory Prostate Cancer
Thymoquinone / Prostate / (In Vitro, In Vivo) - Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
Thymoquinone / Prostate / (In Vitro, In Vivo) - Effects of Thymoquinone–Fatty Acid Conjugates on Cancer Cells
Thymoquinone / Breast, Melanoma, Leukaemia, Uterus-Cervix / (In Vitro) - Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis
Thymoquinone / Leukaemia / (In Vitro) - Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase
Thymoquinone / Colon / (In Vitro) - Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer
Thymoquinone / Colon / (In Vitro, In Vivo) - Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells
Thymoquinone / Colon / (In Vitro) - Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
Thymoquinone / Colon / (In Vitro) - Thymoquinone Triggers Inactivation of the Stress Response Pathway Sensor CHEK1 and Contributes to Apoptosis in Colorectal Cancer Cells
Thymoquinone / Colon / (In Vitro, In Vivo) - Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling
Thymoquinone / Colon / (In Vitro) - Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells
Thymoquinone / Colon / (In Vitro) - Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
Thymoquinone / Colon / (In Vivo) - Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats
Thymoquinone / Colon / (In Vivo) - Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Thymoquinone / Colon / (In Vivo) - Synergism from Combinations of Cisplatin and Oxaliplatin with Quercetin and Thymoquinone in Human Ovarian Tumour Models
Thymoquinone, Quercetin / Ovarian / (In Vitro, Chemo, Synergy) - Cytotoxic and apoptogenic properties of Nigella sativa and thymoquinone, its constituent, in human renal cell carcinoma are comparable with cisplatin
Thymoquinone / Kidney / (In Vitro) - Inhibition of MAPK Kinase Signaling Pathways Suppressed Renal Cell Carcinoma Growth and Angiogenesis In vivo
Thymoquinone / Kidney / (In Vivo) - Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway
Thymoquinone / Lung / (In Vitro) - Cytotoxicity of Nigella Sativa Seed Oil and Extract Against Human Lung Cancer Cell Line
Thymoquinone / Lung / (In Vitro) - Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo
Thymoquinone / Lung / (In Vitro, In Vivo, Chemo, Synergy) - In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone
Thymoquinone / Breast, Ovarian / (In Vitro) - Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells
Thymoquinone / Breast / (In Vitro) - Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer
Thymoquinone, Resveratrol / Breast / (In Vivo, Synergy) - Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
Thymoquinone / Breast / (In Vivo, Chemo, Synergy) - Targeted Apoptotic Effects of Thymoquinone and Tamoxifen on XIAP Mediated Akt Regulation in Breast Cancer
Thymoquinone / Breast / (In Vitro, In Vivo, Chemo, Synergy) - Effects of Thymoquinone in the Expression of Mucin 4 in Pancreatic Cancer Cells: Implications for the Development of Novel Cancer Therapies
Thymoquinone / Pancreatic / (In Vitro) - Downregulation of MUC4 in pancreatic cancer cells by thymoquinone: A promise for pancreatic cancer therapies
Thymoquinone / Pancreatic / (In Vitro) - Thymoquinone-induced E2F-1 downregulation and induction of apoptosis enhances gemcitabine effects in pancreatic cancer
Thymoquinone / Pancreatic / (In Vitro, Chemo, Synergy) - Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer
Thymoquinone / Pancreatic / (In Vitro, In Vivo, Chemo, Synergy) - In vivo modulation of iNOS pathway in hepatocellular carcinoma by Nigella sativa
Thymoquinone / Liver / (In Vivo) - Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition
Thymoquinone / Breast, Melanoma, Uterus-Cervix / (In Vitro, In Vivo) - Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
Thymoquinone / Myeloma / (In Vitro) - Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
Thymoquinone / Myeloma / (In Vitro, In Vivo) - New targets for the treatment of follicular lymphoma
Thymoquinone / Lymphoma / (In Vitro) - Apoptotic effect of Nigella sativa on human lymphoma U937 cells
Thymoquinone / Lymphoma / (In Vitro) - Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
Thymoquinone / Skin / (In Vitro) - Antiproliferative and Proapoptotic Effects of Topotecan in Combination With Thymoquinone on Acute Myelogenous Leukemia
Thymoquinone / Leukaemia / (In Vitro, Chemo, Synergy) - The Anti-Proliferative and Pro-apoptotic Effect of Topotecan in Combination With Thymoquinone in Acute Myelogenous Leukemia
Thymoquinone / Leukaemia / (In Vitro, Chemo, Synergy) - Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cance
Thymoquinone / Ovarian / (In Vivo, Chemo, Synergy) - Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
Thymoquinone / Brain / (In Vitro) - Thymoquinone induces cell death in glioblasotma cell through production of reactive oxygen species and induction of DNA damage
Thymoquinone / Brain / (In Vitro) - Nigella sativa and thymoquinone induce caspase-9/3 activation and glioblastoma cell death
Thymoquinone / Brain / (In Vitro, In Vivo) - Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
Thymoquinone / Leukaemia / (In Vitro, In Vivo) - Thymoquinone Induces Cell Death in Human Squamous Carcinoma Cells via Caspase Activation-Dependent Apoptosis and LC3-II Activation-Dependent Autophagy
Thymoquinone / Oral / (In Vitro, In Vivo) - Triterpenoids Amplify Anti-Tumoral Effects of Mistletoe Extracts on Murine B16.F10 Melanoma In Vivo
Thymoquinone, Mistletoe / Melanoma / (In Vivo, Synergy) - Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone
Thymoquinone / Colon / (In Vitro) - Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer
Thymoquinone / Breast / (In Vitro) - Thymoquinone attenuates phosphorylation of AKT to inhibit kidney cancer cell proliferation
Thymoquinone / Kidney / (In Vitro) - Isolation of thymoquinone from Nigella sativa L. and Thymus vulgaris L., and its anti-proliferative effect on HeLa cancer cell lines
Thymoquinone / Uterus-Cervix / (In Vitro) - Thymoquinone-Induced Tristetraprolin Inhibits Tumor Growth and Metastasis through Destabilization of MUC4 mRNA
Thymoquinone / Melanoma / (In Vitro, In Vivo) - Combination of 5-fluorouracil and thymoquinone targets stem cell gene signature in colorectal cancer cells
Thymoquinone / Colon, Stem_Cell / (In Vitro) - Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms
Thymoquinone / Leukaemia / (In Vitro) - Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
Thymoquinone / Kidney / (In Vitro) - Exploration of pro-apoptotic effect of Thymoquinone on oral squamous cell carcinoma cells through PI3K/Akt signaling pathway
Thymoquinone / Oral / (In Vitro) - Thymoquinone Effects on Cell Viability, Apoptosis and VEGF-A Gene Expression Level in AGS(CRL-1739) Cell Line
Thymoquinone / Gastric / (In Vitro) - Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis
Thymoquinone / Breast, Bone-Cartilage / (In Vitro, In Vivo) - Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticles and Its Cytotoxicity Effects in Tamoxifen-Resistant Breast Cancer Cells
Thymoquinone / Breast / (In Vitro) - Cabazitaxel and thymoquinone co-loaded lipospheres as a synergistic combination for breast cancer
Thymoquinone / Breast / (In Vitro, Chemo, Synergy) - Thymoquinone-induced antitumor and apoptosis in human lung adenocarcinoma cells
Thymoquinone / Lung / (In Vitro) - Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway
Thymoquinone / Kidney / (In Vitro) - Synergistic effect of temozolomide and thymoquinone on human glioblastoma multiforme cell line (U87MG)
Thymoquinone / Brain / (In Vitro, Chemo, Synergy) - Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity in 4T1 tumor-bearing mice
Thymoquinone / Breast / (In Vivo) - Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway
Thymoquinone / Bladder / (In Vitro) - Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer
Thymoquinone / Breast / (In Vitro, In Vivo) - Synergistic effect of thymoquinone and melatonin against breast cancer implanted in mice
Thymoquinone / Breast / (In Vivo, Synergy) - Thymoquinone inhibits metastatic phenotype and epithelial‑mesenchymal transition in renal cell carcinoma by regulating the LKB1/AMPK signaling pathway
Thymoquinone / Kidney / (In Vitro) - Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
Thymoquinone / Brain / (In Vitro) - The effects of thymoquinone and genistein treatment on telomerase activity, apoptosis, angiogenesis, and survival in thyroid cancer cell lines
Thymoquinone / Thyroidal / (In Vitro) - Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice
Thymoquinone / Breast, Uterus-Cervix / (In Vivo) - Cytotoxic Effect of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) on Liver Cancer Cell Integrated with Hepatitis B Genome, Hep3B
Thymoquinone / Liver / (In Vitro)
