RESEARCHES:

• Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo
  Thymoquinone / Breast / (In Vitro, In Vivo)
• Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
  Thymoquinone / Skin / (In Vitro)
• Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma
  Thymoquinone / Skin / (In Vitro, In Vivo)
• The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo
  Thymoquinone / Head_&_Neck, Bone-Cartilage / (In Vitro, In Vivo)
• Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo
  Thymoquinone / Gallbladder / (In Vitro, In Vivo)
• Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53
  Thymoquinone / Breast / (In Vitro)
• Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway
  Thymoquinone / Lung / (In Vitro)
• Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo
  Thymoquinone / Lung / (In Vitro, In Vivo)
• Evaluation of the protective effect of Nigella sativa extract and its primary active component thymoquinone against DMBA-induced breast cancer in female rats
  Thymoquinone / Breast / (In Vivo)
• Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
  Thymoquinone / Breast / (In Vitro)
• Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells
  Thymoquinone / Breast / (In Vitro)
• Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
  Thymoquinone / Breast / (In Vitro)
• Thymoquinone inhibits microtubule polymerization by tubulin binding and causes mitotic arrest following apoptosis in A549 cells
  Thymoquinone / Lung / (In Vitro)
• Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells
  Thymoquinone / Breast / (In Vitro)
• Cellular responses with thymoquinone treatment in human breast cancer cell line MCF-7
  Thymoquinone / Breast / (In Vitro)
• Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
  Thymoquinone / Breast / (In Vivo)
• The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer
  Thymoquinone / Breast / (In Vitro, Chemo, Synergy)
• Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
  Thymoquinone / Leukaemia / (In Vitro)
• Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro
  Thymoquinone / Leukaemia / (In Vitro)
• Thymoquinone induces apoptosis in malignant T-cells via generation of ROS
  Thymoquinone / Leukaemia / (In Vitro)
• Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In Vitro
  Thymoquinone / Leukaemia / (In Vivo)
• Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1
  Thymoquinone / Leukaemia / (In Vitro)
• The effects of thymoquinone and Doxorubicin on leukemia and cardiomyocyte cell lines
  Thymoquinone / Leukaemia / (In Vitro)
• Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
  Thymoquinone / Myeloma / (In Vivo, Chemo, Synergy)
• Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
  Thymoquinone / Myeloma / (In Vitro)
• Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression
  Thymoquinone / Myeloma / (In Vitro)
• Thymoquinone Inhibits the CXCL12-Induced Chemotaxis of Multiple Myeloma Cells and Increases Their Susceptibility to Fas-Mediated Apoptosis
  Thymoquinone / Myeloma / (In Vitro)
• Apoptotic Activities of Thymoquinone, an Active Ingredient of Black Seed (Nigella sativa), in Cervical Cancer Cell Lines
  Thymoquinone / Uterus-Cervix / (In Vitro)
• Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein
  Thymoquinone / Uterus-Cervix / (In Vitro)
• Effects of (-)epigallocatechin gallate and thymoquinone on proliferation of a PANC-1 cell line in culture
  Thymoquinone, EGCG / Pancreatic / (In Vitro)
• Synergistic Combination of Gemcitabine and Dietary Molecule Induces Apoptosis in Pancreatic Cancer Cells and Down Regulates PKM2 Expression
  Thymoquinone / Pancreatic / (In Vitro, Chemo, Synergy)
• Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer
  Thymoquinone / Pancreatic / (In Vitro, In Vivo, Chemo, Synergy)
• Synthesis, characterization and anti-tumor activity of novel thymoquinone analogs against pancreatic cancer
  Thymoquinone / Pancreatic / (In Vitro, Chemo, Synergy)
• Effects of Thymoquinone in the Expression of Mucin 4 in Pancreatic Cancer Cells: Implications for the Development of Novel Cancer Therapies
  Thymoquinone / Pancreatic / (In Vitro)
• Anti-metastasis effect of thymoquinone on human pancreatic cancer.
  Thymoquinone / Pancreatic / (In Vitro, In Vivo)
• Inhibitory effects of thymoquinone on human pancreatic carcinoma orthotopically implanted in nude mice
  Thymoquinone / Pancreatic / (In Vivo)
• Inhibition of epithelial-mesenchymal transition in bladder cancer cells via modulation of mTOR signalling
  Thymoquinone / Bladder / (In Vitro)
• Role of NF-κB in the anti-tumor effect of thymoquinone on bladder cancer
  Thymoquinone / Bladder / (In Vitro, In Vivo)
• Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma
  Thymoquinone / Liver / (In Vivo)
• Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis
  Thymoquinone / Liver / (In Vitro)
• TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
  Thymoquinone / Liver / (In Vitro, In Vivo)
• Thymoquinone Attenuates Diethylnitrosamine Induction of Hepatic Carcinogenesis Through Antioxidant Signaling
  Thymoquinone / Liver / (In Vivo)
• Thymoquinone Anticancer Discovery: Possible Mechanisms
  Thymoquinone / Breast, Colon, Leukaemia, Liver, Gastric / (In Vitro, In Vivo)
• Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo
  Thymoquinone / Gastric / (In Vitro, In Vivo)
• Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
  Thymoquinone / Gastric / (In Vitro, In Vivo)
• Thymoquinone Inhibits Autophagy and Induces Cathepsin-Mediated, Caspase-Independent Cell Death in Glioblastoma Cells
  Thymoquinone / Brain / (In Vitro)
• Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-κB signaling and IL-8 expression
  Thymoquinone / Brain / (In Vitro)
• Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP
  Thymoquinone / Neuro / (In Vitro)
• Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
  Thymoquinone / Brain / (In Vitro)
• Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts
  Thymoquinone / Leukaemia, Brain / (In Vitro)
• Sialidase NEU4 is involved in glioblastoma stem cell survival
  Thymoquinone / Brain, Stem_Cell / (In Vitro)
• Thymoquinone Induces Apoptosis in Oral Cancer Cells Through P38β Inhibition
  Thymoquinone / Oral / (In Vitro)
• Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome
  Thymoquinone / Melanoma / (In Vitro)
• Phosphorylated IκBα Predicts Poor Prognosis in Activated B-Cell Lymphoma and Its Inhibition with Thymoquinone Induces Apoptosis via ROS Release
  Thymoquinone / Lymphoma / (In Vitro)
• Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
  Thymoquinone / Lymphoma / (In Vitro)
• Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway
  Thymoquinone / Bone-Cartilage / (In Vitro, In Vivo)
• Effects of thymoquinone and selenium on the proliferation of MG 63 cells in tissue culture
  Thymoquinone, Selenium / Bone-Cartilage / (In Vitro)
• Thymoquinone rich fraction from Nigella sativa and thymoquinone are cytotoxic towards colon and leukemic carcinoma cell lines
  Thymoquinone / Colon, Leukaemia / (In Vitro)
• Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species
  Thymoquinone / Prostate / (In Vitro)
• Androgen Receptor– and E2F-1–Targeted Thymoquinone Therapy for Hormone-Refractory Prostate Cancer
  Thymoquinone / Prostate / (In Vitro, In Vivo)
• Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
  Thymoquinone / Prostate / (In Vitro, In Vivo)
• Effects of Thymoquinone–Fatty Acid Conjugates on Cancer Cells
  Thymoquinone / Breast, Melanoma, Leukaemia, Uterus-Cervix / (In Vitro)
• Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis
  Thymoquinone / Leukaemia / (In Vitro)
• Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase
  Thymoquinone / Colon / (In Vitro)
• Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer
  Thymoquinone / Colon / (In Vitro, In Vivo)
• Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells
  Thymoquinone / Colon / (In Vitro)
• Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
  Thymoquinone / Colon / (In Vitro)
• Thymoquinone Triggers Inactivation of the Stress Response Pathway Sensor CHEK1 and Contributes to Apoptosis in Colorectal Cancer Cells
  Thymoquinone / Colon / (In Vitro, In Vivo)
• Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling
  Thymoquinone / Colon / (In Vitro)
• Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells
  Thymoquinone / Colon / (In Vitro)
• Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
  Thymoquinone / Colon / (In Vivo)
• Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats
  Thymoquinone / Colon / (In Vivo)
• Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
  Thymoquinone / Colon / (In Vivo)
• Synergism from Combinations of Cisplatin and Oxaliplatin with Quercetin and Thymoquinone in Human Ovarian Tumour Models
  Thymoquinone, Quercetin / Ovarian / (In Vitro, Chemo, Synergy)
• Cytotoxic and apoptogenic properties of Nigella sativa and thymoquinone, its constituent, in human renal cell carcinoma are comparable with cisplatin
  Thymoquinone / Kidney / (In Vitro)
• Inhibition of MAPK Kinase Signaling Pathways Suppressed Renal Cell Carcinoma Growth and Angiogenesis In vivo
  Thymoquinone / Kidney / (In Vivo)
• Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway
  Thymoquinone / Lung / (In Vitro)
• Cytotoxicity of Nigella Sativa Seed Oil and Extract Against Human Lung Cancer Cell Line
  Thymoquinone / Lung / (In Vitro)
• Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo
  Thymoquinone / Lung / (In Vitro, In Vivo, Chemo, Synergy)
• In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone
  Thymoquinone / Breast, Ovarian / (In Vitro)
• Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells
  Thymoquinone / Breast / (In Vitro)
• Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer
  Thymoquinone, Resveratrol / Breast / (In Vivo, Synergy)
• Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
  Thymoquinone / Breast / (In Vivo, Chemo, Synergy)
• Targeted Apoptotic Effects of Thymoquinone and Tamoxifen on XIAP Mediated Akt Regulation in Breast Cancer
  Thymoquinone / Breast / (In Vitro, In Vivo, Chemo, Synergy)
• Effects of Thymoquinone in the Expression of Mucin 4 in Pancreatic Cancer Cells: Implications for the Development of Novel Cancer Therapies
  Thymoquinone / Pancreatic / (In Vitro)
• Downregulation of MUC4 in pancreatic cancer cells by thymoquinone: A promise for pancreatic cancer therapies
  Thymoquinone / Pancreatic / (In Vitro)
• Thymoquinone-induced E2F-1 downregulation and induction of apoptosis enhances gemcitabine effects in pancreatic cancer
  Thymoquinone / Pancreatic / (In Vitro, Chemo, Synergy)
• Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer
  Thymoquinone / Pancreatic / (In Vitro, In Vivo, Chemo, Synergy)
• In vivo modulation of iNOS pathway in hepatocellular carcinoma by Nigella sativa
  Thymoquinone / Liver / (In Vivo)
• Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition
  Thymoquinone / Breast, Melanoma, Uterus-Cervix / (In Vitro, In Vivo)
• Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
  Thymoquinone / Myeloma / (In Vitro)
• Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
  Thymoquinone / Myeloma / (In Vitro, In Vivo)
• New targets for the treatment of follicular lymphoma
  Thymoquinone / Lymphoma / (In Vitro)
• Apoptotic effect of Nigella sativa on human lymphoma U937 cells
  Thymoquinone / Lymphoma / (In Vitro)
• Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
  Thymoquinone / Skin / (In Vitro)
• Antiproliferative and Proapoptotic Effects of Topotecan in Combination With Thymoquinone on Acute Myelogenous Leukemia
  Thymoquinone / Leukaemia / (In Vitro, Chemo, Synergy)
• The Anti-Proliferative and Pro-apoptotic Effect of Topotecan in Combination With Thymoquinone in Acute Myelogenous Leukemia
  Thymoquinone / Leukaemia / (In Vitro, Chemo, Synergy)
• Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cance
  Thymoquinone / Ovarian / (In Vivo, Chemo, Synergy)
• Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
  Thymoquinone / Brain / (In Vitro)
• Thymoquinone induces cell death in glioblasotma cell through production of reactive oxygen species and induction of DNA damage
  Thymoquinone / Brain / (In Vitro)
• Nigella sativa and thymoquinone induce caspase-9/3 activation and glioblastoma cell death
  Thymoquinone / Brain / (In Vitro, In Vivo)
• Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
  Thymoquinone / Leukaemia / (In Vitro, In Vivo)
• Thymoquinone Induces Cell Death in Human Squamous Carcinoma Cells via Caspase Activation-Dependent Apoptosis and LC3-II Activation-Dependent Autophagy
  Thymoquinone / Oral / (In Vitro, In Vivo)
• Triterpenoids Amplify Anti-Tumoral Effects of Mistletoe Extracts on Murine B16.F10 Melanoma In Vivo
  Thymoquinone, Mistletoe / Melanoma / (In Vivo, Synergy)
• Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone
  Thymoquinone / Colon / (In Vitro)
• Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer
  Thymoquinone / Breast / (In Vitro)
• Thymoquinone attenuates phosphorylation of AKT to inhibit kidney cancer cell proliferation
  Thymoquinone / Kidney / (In Vitro)
• Isolation of thymoquinone from Nigella sativa L. and Thymus vulgaris L., and its anti-proliferative effect on HeLa cancer cell lines
  Thymoquinone / Uterus-Cervix / (In Vitro)
• Thymoquinone-Induced Tristetraprolin Inhibits Tumor Growth and Metastasis through Destabilization of MUC4 mRNA
  Thymoquinone / Melanoma / (In Vitro, In Vivo)
• Combination of 5-fluorouracil and thymoquinone targets stem cell gene signature in colorectal cancer cells
  Thymoquinone / Colon, Stem_Cell / (In Vitro)
• Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms
  Thymoquinone / Leukaemia / (In Vitro)
• Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
  Thymoquinone / Kidney / (In Vitro)
• Exploration of pro-apoptotic effect of Thymoquinone on oral squamous cell carcinoma cells through PI3K/Akt signaling pathway
  Thymoquinone / Oral / (In Vitro)
• Thymoquinone Effects on Cell Viability, Apoptosis and VEGF-A Gene Expression Level in AGS(CRL-1739) Cell Line
  Thymoquinone / Gastric / (In Vitro)
• Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis
  Thymoquinone / Breast, Bone-Cartilage / (In Vitro, In Vivo)
• Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticles and Its Cytotoxicity Effects in Tamoxifen-Resistant Breast Cancer Cells
  Thymoquinone / Breast / (In Vitro)
• Cabazitaxel and thymoquinone co-loaded lipospheres as a synergistic combination for breast cancer
  Thymoquinone / Breast / (In Vitro, Chemo, Synergy)
• Thymoquinone-induced antitumor and apoptosis in human lung adenocarcinoma cells
  Thymoquinone / Lung / (In Vitro)
• Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway
  Thymoquinone / Kidney / (In Vitro)
• Synergistic effect of temozolomide and thymoquinone on human glioblastoma multiforme cell line (U87MG)
  Thymoquinone / Brain / (In Vitro, Chemo, Synergy)
• Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity in 4T1 tumor-bearing mice
  Thymoquinone / Breast / (In Vivo)
• Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway
  Thymoquinone / Bladder / (In Vitro)
• Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer
  Thymoquinone / Breast / (In Vitro, In Vivo)
• Synergistic effect of thymoquinone and melatonin against breast cancer implanted in mice
  Thymoquinone / Breast / (In Vivo, Synergy)
• Thymoquinone inhibits metastatic phenotype and epithelial‑mesenchymal transition in renal cell carcinoma by regulating the LKB1/AMPK signaling pathway
  Thymoquinone / Kidney / (In Vitro)
• Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
  Thymoquinone / Brain / (In Vitro)
• The effects of thymoquinone and genistein treatment on telomerase activity, apoptosis, angiogenesis, and survival in thyroid cancer cell lines
  Thymoquinone / Thyroidal / (In Vitro)
• Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice
  Thymoquinone / Breast, Uterus-Cervix / (In Vivo)
• Cytotoxic Effect of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) on Liver Cancer Cell Integrated with Hepatitis B Genome, Hep3B
  Thymoquinone / Liver / (In Vitro)