RESEARCHES:

• Inhibition of Tumor Cellular Proteasome Activity by Triptolide Extracted from the Chinese Medicinal Plant ‘Thunder God Vine’
  Tripterygium_W / Breast, Prostate / (In Vitro)
• Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway
  Tripterygium_W / Uterus-Cervix / (In Vitro)
• Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway
  Tripterygium_W / Uterus-Cervix / (In Vitro)
• Growth inhibition effect of triptolide on human endometrial cancer cells in vivo
  Tripterygium_W / Uterus-Cervix / (In Vivo)
• Effect of triptolide on proliferation and apoptosis,cycloxygenase-2 and survivin mRNA expression in squamous carcinoma cell line A431
  Tripterygium_W / Skin / (In Vitro)
• Triptolide-induced in vitro and in vivo cytotoxicity in human breast cancer stem cells and primary breast cancer cells
  Tripterygium_W / Breast, Stem_Cell / (In Vitro, In Vivo)
• Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo
  Tripterygium_W / Gastric / (In Vitro, In Vivo, Chemo, Synergy)
• Celastrol Induces Apoptosis of Gastric Cancer Cells by miR-21 Inhibiting PI3K/Akt-NF-κB Signaling Pathway
  Tripterygium_W / Gastric / (In Vitro)
• Apoptosis induced by triptolide in human gastric cancer is dependent on the constitutive expression of wild type p53 and activation of caspases
  Tripterygium_W / Gastric / (In Vitro)
• Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
  Tripterygium_W / Gastric / (In Vitro, In Vivo)
• Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines
  Tripterygium_W / Lymphoma, Leukaemia, Liver / (In Vitro)
• Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21
  Tripterygium_W / Colon / (In Vitro)
• Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon
  Tripterygium_W / Colon / (In Vitro, In Vivo)
• Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression
  Tripterygium_W / Colon / (In Vitro, In Vivo)
• Triptolide Synergistically Enhances Antitumor Activity of Oxaliplatin in Colon Carcinoma In Vitro and In Vivo
  Tripterygium_W / Colon / (In Vitro, In Vivo, Chemo, Synergy)
• PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy
  Tripterygium_W / Lung, Colon, Bone-Cartilage / (In Vitro, In Vivo, Chemo, Synergy)
• Antiproliferative and Proapoptotic Activities of Triptolide (PG490), a Natural Product Entering Clinical Trials, on Primary Cultures of Human Prostatic Epithelial Cells
  Tripterygium_W / Prostate / (In Vitro)
• Celastrol, a Triterpene Extracted from the Chinese “Thunder of God Vine,” Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice
  Tripterygium_W / Prostate / (In Vitro, In Vivo)
• Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
  Tripterygium_W / Prostate / (In Vitro, In Vivo)
• Triptolide Induces Growth Inhibition and Apoptosis of Human Laryngocarcinoma Cells by Enhancing p53 Activities and Suppressing E6-Mediated p53 Degradation
  Tripterygium_W / Oral / (In Vitro)
• Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo
  Tripterygium_W / Oral / (In Vitro, In Vivo)
• Triptolide has antitumor effects in lung cancer via Wnt pathway inhibition.
  Tripterygium_W / Lung / (In Vitro, In Vivo)
• Minnelide: A Novel Therapeutic That Promotes Apoptosis in Non-Small Cell Lung Carcinoma In Vivo
  Tripterygium_W / Lung / (In Vitro, In Vivo)
• Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma
  Tripterygium_W / Lung / (In Vitro, In Vivo)
• PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy
  Tripterygium_W / Lung, Colon, Bone-Cartilage / (In Vitro, In Vivo, Chemo, Synergy)
• Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine
  Tripterygium_W / Lung, Breast, Colon, Liver, Gastric, Ovarian, Uterus-Cervix / (In Vitro, In Vivo)
• Triptolide reverses hypoxia-induced epithelial–mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation
  Tripterygium_W / Pancreatic / (In Vitro, In Vivo)
• Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated by O-GlcNAc Modification of Transcription Factor Sp1*
  Tripterygium_W / Pancreatic / (In Vitro, In Vivo)
• Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells
  Tripterygium_W / Pancreatic / (In Vitro)
• Triptolide Induces Pancreatic Cancer Cell Death via Inhibition of Heat Shock Protein 70
  Tripterygium_W / Pancreatic / (In Vitro, In Vivo)
• Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model
  Tripterygium_W / Pancreatic / (In Vitro, In Vivo)
• Triptolide inhibits tumor growth and local-regional spread in vivo via increased apoptosis and decreased heat shock protein 70 (hsp70)
  Tripterygium_W / Pancreatic / (In Vitro, In Vivo)
• Establishment of an Allo-Transplantable Hamster Cholangiocarcinoma Cell Line and Its Application for In Vivo Screening of Anti-Cancer Drugs
  Tripterygium_W / Gallbladder / (In Vitro, In Vivo)
• Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
  Tripterygium_W / Leukaemia / (In Vitro)
• Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells
  Tripterygium_W / Leukaemia / (In Vitro)
• Effects of Triptolide on HL-60 Cell in vitro and in vivo
  Tripterygium_W / Leukaemia / (In Vitro, In Vivo)
• Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation
  Tripterygium_W / Leukaemia / (In Vitro, In Vivo)
• Triptolide Down-regulates Bcr-abl Expression and Induces Apoptosis in Chronic Myelogenous Leukemia Cells
  Tripterygium_W / Leukaemia / (In Vitro)
• Triptolide induces apoptosis of PMA-treated THP-1 cells through activation of caspases, inhibition of NF-κB and activation of MAPKs
  Tripterygium_W / Leukaemia / (In Vitro)
• Triptolide induced cell death through apoptosis and autophagy in murine leukemia WEHI-3 cells in vitro and promoting immune responses in WEHI-3 generated leukemia mice in vivo
  Tripterygium_W / Leukaemia / (In Vitro, In Vivo)
• Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors
  Tripterygium_W / Leukaemia / (In Vitro, Chemo, Synergy)
• Triptolide sensitizes liver cancer cell lines to chemotherapy in vitro and in vivo.
  Tripterygium_W / Liver / (In Vitro, In Vivo, Chemo, Synergy)
• Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters
  Tripterygium_W / Gallbladder / (In Vitro, In Vivo)
• Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo
  Tripterygium_W / Liver / (In Vitro, In Vivo)
• Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells
  Tripterygium_W / Lung, Liver / (In Vitro)
• Triptolide Induces S Phase Arrest and Apoptosis in Gallbladder Cancer Cells
  Tripterygium_W / Gallbladder / (In Vitro)
• Triptolide-induced in vitro and in vivo cytotoxicity in human breast cancer stem cells and primary breast cancer cells
  Tripterygium_W / Breast / (In Vitro, In Vivo)
• Anti-cancer and Sensibilisation Effect of Triptolide on Human Epithelial Ovarian Cancer
  Tripterygium_W / Ovarian / (In Vitro, In Vivo, Chemo, Synergy)
• Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
  Tripterygium_W / Ovarian / (In Vitro, In Vivo)
• Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB
  Tripterygium_W / Ovarian / (In Vitro, In Vivo)
• Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1
  Tripterygium_W / Myeloma / (In Vitro)
• Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1-mediated NF-κB activation
  Tripterygium_W / Lung, Bladder, Leukaemia, Kidney, Myeloma / (In Vitro)
• Effective therapy for advanced renal cell carcinoma using triptolide and TRAIL receptor agonists
  Tripterygium_W / Kidney / (In Vitro, In Vivo)
• Inhibitory Effects of Triptolide Nanovehicles on Tumor Growth and Metastases
  Tripterygium_W / Melanoma / (In Vitro, In Vivo)
• A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-Regulation of the Nuclear Factor-κB Pathway
  Tripterygium_W / Thyroidal / (In Vitro)
• Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro
  Tripterygium_W / Bone-Cartilage / (In Vitro, In Vivo)
• Effect of Triptolide on Malignant Peripheral Nerve Sheath Tumours In Vitro and In Vivo
  Tripterygium_W / Neuro / (In Vitro, In Vivo)
• Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo
  Tripterygium_W / Neuro / (In Vitro, In Vivo)
• Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo
  Tripterygium_W / Neuro / (In Vitro, In Vivo)
• Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine
  Tripterygium_W / Lung / (In Vitro, In Vivo, Synergy)
• Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis
  Tripterygium_W / Prostate, Bone-Cartilage / (In Vitro, In Vivo)
• Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
  Tripterygium_W / Colon, Pancreatic / (In Vitro)
• Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs
  Tripterygium_W / Kidney, Uterus-Cervix / (In Vitro, Chemo, Synergy)
• Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo
  Tripterygium_W / Liver / (In Vitro, In Vivo)
• miR-224 is Critical for Celastrol-Induced Inhibition of Migration and Invasion of Hepatocellular Carcinoma Cells
  Tripterygium_W / Liver / (In Vitro)
• Celastrol Induces Mitochondria-Mediated Apoptosis in Hepatocellular Carcinoma Bel-7402 Cells Read More: http://www.worldscientific.com/doi/abs/10.1142/S0192415X15500093
  Tripterygium_W / Liver / (In Vitro)
• Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity
  Tripterygium_W / Liver / (In Vitro, In Vivo)
• Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo
  Tripterygium_W / Liver / (In Vitro, In Vivo)
• Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts
  Tripterygium_W / Liver / (In Vitro, In Vivo)
• Celastrol-mediated growth inhibition of subcutaneously transplanted hepatocarcinoma in nude mice
  Tripterygium_W / Liver / (In Vivo)
• Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
  Tripterygium_W / Brain / (In Vitro, Chemo, Synergy)
• Pharmacogenomic Approach Reveals a Role for the xc− Cystine/Glutamate Antiporter in Growth and Celastrol Resistance of Glioma Cell Lines
  Tripterygium_W / Brain / (In Vitro)
• Celastrol inhibits human glioma xenograft
  Tripterygium_W / Brain / (In Vivo)
• Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study.
  Tripterygium_W / Brain / (In Vitro, In Vivo)
• Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
  Tripterygium_W / Brain / (In Vivo)
• Celastrol Blocks Interleukin-6 Gene Expression via Downregulation of NF-κB in Prostate Carcinoma Cells
  Tripterygium_W / Prostate / (In Vitro)
• Effect of Celastrol on Growth Inhibition of Prostate Cancer Cells through the Regulation of hERG Channel In Vitro
  Tripterygium_W / Prostate / (In Vitro, In Vivo)
• Celastrol Induces Autophagy by Targeting AR/miR-101 in Prostate Cancer Cells
  Tripterygium_W / Prostate / (In Vitro)
• Celastrol Potentiates Radiotherapy by Impairment of DNA Damage Processing in Human Prostate Cancer
  Tripterygium_W / Prostate / (In Vitro, In Vivo, Chemo, Synergy)
• Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB
  Tripterygium_W / Prostate / (In Vitro, In Vivo)
• Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer
  Tripterygium_W / Prostate / (In Vitro, In Vivo)
• Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling
  Tripterygium_W / Prostate, Stem_Cell / (In Vitro)
• Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
  Tripterygium_W / Lung, Prostate, Uterus-Cervix / (In Vitro)
• Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study
  Tripterygium_W / Bone-Cartilage / (In Vitro, In Vivo)
• Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α
  Tripterygium_W / Breast / (In Vitro)
• Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9
  Tripterygium_W / Breast / (In Vitro)
• Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol
  Tripterygium_W / Breast, Prostate / (In Vitro)
• Pharmacologic inhibitors of IκB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo
  Tripterygium_W / Bone-Cartilage / (In Vitro, In Vivo)
• Synergistic Anti-Cancer Activity by the Combination of TRAIL/APO-2L and Celastrol
  Tripterygium_W / Lung, Colon, Ovarian / (In Vitro, In Vivo)
• Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
  Tripterygium_W / Breast / (In Vitro, In Vivo, Chemo, Synergy)
• Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer
  Tripterygium_W / Gastric / (In Vitro)
• The research of Celastrol on its effect of inducing gastric cancer cell line MGC803 apoptosis
  Tripterygium_W / Gastric / (In Vitro)
• Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
  Tripterygium_W / Gastric / (In Vitro, In Vivo)
• A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
  Tripterygium_W / Pancreatic / (In Vitro, In Vivo)
• Inhibition of Autophagy Strengthens Celastrol-Induced Apoptosis in Human Pancreatic Cancer In Vitro and In Vivo Models
  Tripterygium_W / Pancreatic / (In Vitro, In Vivo)
• Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells
  Tripterygium_W / Bladder / (In Vitro, In Vivo)
• Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways
  Tripterygium_W / Lung / (In Vitro)
• Formulation and Evaluation of Celastrol-Loaded Liposomes
  Tripterygium_W / Lung / (In Vivo)
• Overcoming cisplatin resistance by celastrol in cancer cells.
  Tripterygium_W / Lung / (In Vitro, Chemo, Synergy)
• Synergistic Antitumor Activity of Gemcitabine and ABT-737 In Vitro and In Vivo through Disrupting the Interaction of USP9X and Mcl-1
  Tripterygium_W / Lung / (In Vitro, In Vivo, Chemo, Synergy)
• ATF2 contributes to cisplatin resistance in non-small cell lung cancer and celastrol induces cisplatin resensitization through inhibition of JNK/ATF2 pathway
  Tripterygium_W / Lung / (In Vitro, Chemo, Synergy)
• Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
  Tripterygium_W / Myeloma / (In Vitro, Chemo, Synergy)
• NF-Kappa B Modulation Is Involved in Celastrol Induced Human Multiple Myeloma Cell Apoptosis
  Tripterygium_W / Myeloma / (In Vitro)
• Apoptosis induced by celastrol on multiple cell lines and the effect on cell cycle
  Tripterygium_W / Myeloma / (In Vitro)
• Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-κB pathway
  Tripterygium_W / Myeloma / (In Vitro)
• HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
  Tripterygium_W / Leukaemia / (In Vitro)
• Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol
  Tripterygium_W / Leukaemia / (In Vitro)
• Inhibition of c-myc by the triterpenoid celastrol
  Tripterygium_W / Leukaemia / (In Vitro)
• Effects of triptolide on cell proliferation and CXCR4 expression in Burkitt’s lymphoma Raji cells in vitro
  Tripterygium_W / Lymphoma / (In Vitro)
• Efficacy, pharmacokinetics and tissue distribution of celastrol analogues SBI 064601, SBI 0640599 and SBI 0069272 in C.B-17 SCID mice bearing Daudi Burkitt\\
  Tripterygium_W / Lymphoma / (In Vivo)
• Celastrol, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation
  Tripterygium_W / Leukaemia / (In Vitro, In Vivo)
• Celastrol induces unfolded protein response-dependent cell death in head and neck cancer
  Tripterygium_W / Head_&_Neck / (In Vitro)
• Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer
  Tripterygium_W / Lung / (In Vitro, In Vivo)
• Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo
  Tripterygium_W / Lung, Prostate, Ovarian / (In Vitro, In Vivo, Chemo, Synergy)
• Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells
  Tripterygium_W / Colon / (In Vitro)
• Enhanced anti-tumor activity by the combination of TRAIL/Apo-2L and combretastatin A-4 against human colon cancer cells via induction of apoptosis in vitro and in vivo
  Tripterygium_W / Colon / (In Vitro, In Vivo, Chemo, Synergy)
• Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling
  Tripterygium_W / Melanoma / (In Vitro)
• Celastrol Synergistically Enhances Temozolomide Cytotoxicity in Melanoma Cells
  Tripterygium_W / Melanoma / (In Vitro, Chemo, Synergy)
• Preclinical Studies of Celastrol and Acetyl Isogambogic Acid in Melanoma
  Tripterygium_W / Melanoma / (In Vitro, In Vivo)
• Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis
  Tripterygium_W / Lung, Breast, Prostate, Liver, Uterus-Cervix / (In Vitro)
• Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation
  Tripterygium_W / Lung / (In Vitro)
• Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography–mass spectrometry based metabolic profiling
  Tripterygium_W / Uterus-Cervix / (In Vitro)
• Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells
  Tripterygium_W / Uterus-Cervix, Head_&_Neck / (In Vitro, In Vivo, Chemo, Synergy)
• Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance.
  Tripterygium_W / Lung / (In Vitro)
• Celastrol inhibits high fat diet-induced obesity and intestinal tumorigenesis in APCMin/+ mice by modulating gut microbes and inflammation
  Tripterygium_W / Colon, Gastric / (In Vivo)
• Celastrol inhibits cancer metastasis by suppressing M2-like polarization of macrophages
  Tripterygium_W / Breast / (In Vitro, In Vivo)
• Celastrol strongly inhibits proliferation, migration and cancer stem cell properties through suppression of Pin1 in ovarian cancer cells
  Tripterygium_W / Ovarian, Stem_Cell / (In Vitro)
• Celastrol Binds to HSP90 Trigger Functional Protein Interaction Network Against Pancreatic Cancer
  Tripterygium_W / Pancreatic / (In Vitro)
• Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis
  Tripterygium_W / Colon / (In Vitro)
• Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
  Tripterygium_W / Ovarian / (In Vitro, In Vivo)
• Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species
  Tripterygium_W / Lung / (In Vitro, Chemo, Synergy)
• Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
  Tripterygium_W / Colon / (In Vitro)
• Triptolide inhibits the growth and migration of colon carcinoma cells by down-regulation of miR-191
  Tripterygium_W / Colon / (In Vitro, In Vivo)
• Triptolide suppresses the proliferation and induces the apoptosis of nasopharyngeal carcinoma cells via the PI3K/Akt pathway
  Tripterygium_W / Head_&_Neck / (In Vitro)
• Triptolide interferes with XRCC1/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin
  Tripterygium_W / Breast / (In Vitro, Chemo, Synergy)
• Triptolide suppresses growth of breast cancer by targeting HMGB1 in vitro and in vivo
  Tripterygium_W / Breast / (In Vitro, In Vivo)
• The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
  Tripterygium_W / Lung / (In Vitro)
• Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine by inhibiting TLR4/NF-κB signaling
  Tripterygium_W / Pancreatic / (In Vitro)
• Triptolide reduces proliferation and enhances apoptosis in drug-resistant human oral cancer cells
  Tripterygium_W / Oral / (In Vitro)
• Celastrol, a plant-derived triterpene, induces cisplatin-resistance nasopharyngeal carcinoma cancer cell apoptosis though ERK1/2 and p38 MAPK signaling pathway
  Tripterygium_W / Head_&_Neck / (In Vitro)
• Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species
  Tripterygium_W / Lung / (In Vitro, Chemo, Synergy)
• Celastrol induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity
  Tripterygium_W / Myeloma / (In Vitro)
• Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells
  Tripterygium_W / Lung / (In Vitro, Chemo, Synergy)
• Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer
  Tripterygium_W / Colon / (In Vitro)
• Celastrol Enhances the Anti-Liver Cancer Activity of Sorafenib
  Tripterygium_W / Liver / (In Vitro, Chemo, Synergy)
• Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway
  Tripterygium_W / Brain / (In Vitro, Chemo, Synergy)