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Research Base – Cancer – Tripterygium wilfordiithe admin2020-10-02T10:28:27-01:00Thunder god vine, Yellow Vine, Huang-T’eng Ken, Lei Gong Teng, Raikoto, Lei-Kung T’eng, Taso-Ho-Hua, Threewingnut, Tonnerre de la Vigne de Dieu, Vigne du Tonnerre Divin.
A herb that is widespread in China, Korea and Japan, used in these areas as a cure for various diseases for more than 400 years.. In the western world, it is best known for treating rheumatic arthritis, autoimmune diseases, inflammation, support the immune system, and it may be a male contraceptive. The remedy is made from the root of this herb, and the most important ingredient actually considered to be healing is known as TRIPTOLIDE. The second important ingredient is CELASTROL.
RESEARCHES:
- Inhibition of Tumor Cellular Proteasome Activity by Triptolide Extracted from the Chinese Medicinal Plant ‘Thunder God Vine’
Tripterygium_W / Breast, Prostate / (In Vitro) - Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway
Tripterygium_W / Uterus-Cervix / (In Vitro) - Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway
Tripterygium_W / Uterus-Cervix / (In Vitro) - Growth inhibition effect of triptolide on human endometrial cancer cells in vivo
Tripterygium_W / Uterus-Cervix / (In Vivo) - Effect of triptolide on proliferation and apoptosis,cycloxygenase-2 and survivin mRNA expression in squamous carcinoma cell line A431
Tripterygium_W / Skin / (In Vitro) - Triptolide-induced in vitro and in vivo cytotoxicity in human breast cancer stem cells and primary breast cancer cells
Tripterygium_W / Breast, Stem_Cell / (In Vitro, In Vivo) - Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo
Tripterygium_W / Gastric / (In Vitro, In Vivo, Chemo, Synergy) - Celastrol Induces Apoptosis of Gastric Cancer Cells by miR-21 Inhibiting PI3K/Akt-NF-κB Signaling Pathway
Tripterygium_W / Gastric / (In Vitro) - Apoptosis induced by triptolide in human gastric cancer is dependent on the constitutive expression of wild type p53 and activation of caspases
Tripterygium_W / Gastric / (In Vitro) - Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
Tripterygium_W / Gastric / (In Vitro, In Vivo) - Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines
Tripterygium_W / Lymphoma, Leukaemia, Liver / (In Vitro) - Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21
Tripterygium_W / Colon / (In Vitro) - Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon
Tripterygium_W / Colon / (In Vitro, In Vivo) - Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression
Tripterygium_W / Colon / (In Vitro, In Vivo) - Triptolide Synergistically Enhances Antitumor Activity of Oxaliplatin in Colon Carcinoma In Vitro and In Vivo
Tripterygium_W / Colon / (In Vitro, In Vivo, Chemo, Synergy) - PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy
Tripterygium_W / Lung, Colon, Bone-Cartilage / (In Vitro, In Vivo, Chemo, Synergy) - Antiproliferative and Proapoptotic Activities of Triptolide (PG490), a Natural Product Entering Clinical Trials, on Primary Cultures of Human Prostatic Epithelial Cells
Tripterygium_W / Prostate / (In Vitro) - Celastrol, a Triterpene Extracted from the Chinese “Thunder of God Vine,” Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice
Tripterygium_W / Prostate / (In Vitro, In Vivo) - Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
Tripterygium_W / Prostate / (In Vitro, In Vivo) - Triptolide Induces Growth Inhibition and Apoptosis of Human Laryngocarcinoma Cells by Enhancing p53 Activities and Suppressing E6-Mediated p53 Degradation
Tripterygium_W / Oral / (In Vitro) - Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo
Tripterygium_W / Oral / (In Vitro, In Vivo) - Triptolide has antitumor effects in lung cancer via Wnt pathway inhibition.
Tripterygium_W / Lung / (In Vitro, In Vivo) - Minnelide: A Novel Therapeutic That Promotes Apoptosis in Non-Small Cell Lung Carcinoma In Vivo
Tripterygium_W / Lung / (In Vitro, In Vivo) - Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma
Tripterygium_W / Lung / (In Vitro, In Vivo) - PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy
Tripterygium_W / Lung, Colon, Bone-Cartilage / (In Vitro, In Vivo, Chemo, Synergy) - Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine
Tripterygium_W / Lung, Breast, Colon, Liver, Gastric, Ovarian, Uterus-Cervix / (In Vitro, In Vivo) - Triptolide reverses hypoxia-induced epithelial–mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation
Tripterygium_W / Pancreatic / (In Vitro, In Vivo) - Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated by O-GlcNAc Modification of Transcription Factor Sp1*
Tripterygium_W / Pancreatic / (In Vitro, In Vivo) - Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells
Tripterygium_W / Pancreatic / (In Vitro) - Triptolide Induces Pancreatic Cancer Cell Death via Inhibition of Heat Shock Protein 70
Tripterygium_W / Pancreatic / (In Vitro, In Vivo) - Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model
Tripterygium_W / Pancreatic / (In Vitro, In Vivo) - Triptolide inhibits tumor growth and local-regional spread in vivo via increased apoptosis and decreased heat shock protein 70 (hsp70)
Tripterygium_W / Pancreatic / (In Vitro, In Vivo) - Establishment of an Allo-Transplantable Hamster Cholangiocarcinoma Cell Line and Its Application for In Vivo Screening of Anti-Cancer Drugs
Tripterygium_W / Gallbladder / (In Vitro, In Vivo) - Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
Tripterygium_W / Leukaemia / (In Vitro) - Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells
Tripterygium_W / Leukaemia / (In Vitro) - Effects of Triptolide on HL-60 Cell in vitro and in vivo
Tripterygium_W / Leukaemia / (In Vitro, In Vivo) - Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation
Tripterygium_W / Leukaemia / (In Vitro, In Vivo) - Triptolide Down-regulates Bcr-abl Expression and Induces Apoptosis in Chronic Myelogenous Leukemia Cells
Tripterygium_W / Leukaemia / (In Vitro) - Triptolide induces apoptosis of PMA-treated THP-1 cells through activation of caspases, inhibition of NF-κB and activation of MAPKs
Tripterygium_W / Leukaemia / (In Vitro) - Triptolide induced cell death through apoptosis and autophagy in murine leukemia WEHI-3 cells in vitro and promoting immune responses in WEHI-3 generated leukemia mice in vivo
Tripterygium_W / Leukaemia / (In Vitro, In Vivo) - Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors
Tripterygium_W / Leukaemia / (In Vitro, Chemo, Synergy) - Triptolide sensitizes liver cancer cell lines to chemotherapy in vitro and in vivo.
Tripterygium_W / Liver / (In Vitro, In Vivo, Chemo, Synergy) - Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters
Tripterygium_W / Gallbladder / (In Vitro, In Vivo) - Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo
Tripterygium_W / Liver / (In Vitro, In Vivo) - Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells
Tripterygium_W / Lung, Liver / (In Vitro) - Triptolide Induces S Phase Arrest and Apoptosis in Gallbladder Cancer Cells
Tripterygium_W / Gallbladder / (In Vitro) - Triptolide-induced in vitro and in vivo cytotoxicity in human breast cancer stem cells and primary breast cancer cells
Tripterygium_W / Breast / (In Vitro, In Vivo) - Anti-cancer and Sensibilisation Effect of Triptolide on Human Epithelial Ovarian Cancer
Tripterygium_W / Ovarian / (In Vitro, In Vivo, Chemo, Synergy) - Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
Tripterygium_W / Ovarian / (In Vitro, In Vivo) - Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB
Tripterygium_W / Ovarian / (In Vitro, In Vivo) - Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1
Tripterygium_W / Myeloma / (In Vitro) - Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1-mediated NF-κB activation
Tripterygium_W / Lung, Bladder, Leukaemia, Kidney, Myeloma / (In Vitro) - Effective therapy for advanced renal cell carcinoma using triptolide and TRAIL receptor agonists
Tripterygium_W / Kidney / (In Vitro, In Vivo) - Inhibitory Effects of Triptolide Nanovehicles on Tumor Growth and Metastases
Tripterygium_W / Melanoma / (In Vitro, In Vivo) - A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-Regulation of the Nuclear Factor-κB Pathway
Tripterygium_W / Thyroidal / (In Vitro) - Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro
Tripterygium_W / Bone-Cartilage / (In Vitro, In Vivo) - Effect of Triptolide on Malignant Peripheral Nerve Sheath Tumours In Vitro and In Vivo
Tripterygium_W / Neuro / (In Vitro, In Vivo) - Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo
Tripterygium_W / Neuro / (In Vitro, In Vivo) - Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo
Tripterygium_W / Neuro / (In Vitro, In Vivo) - Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine
Tripterygium_W / Lung / (In Vitro, In Vivo, Synergy) - Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis
Tripterygium_W / Prostate, Bone-Cartilage / (In Vitro, In Vivo) - Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
Tripterygium_W / Colon, Pancreatic / (In Vitro) - Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs
Tripterygium_W / Kidney, Uterus-Cervix / (In Vitro, Chemo, Synergy) - Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo
Tripterygium_W / Liver / (In Vitro, In Vivo) - miR-224 is Critical for Celastrol-Induced Inhibition of Migration and Invasion of Hepatocellular Carcinoma Cells
Tripterygium_W / Liver / (In Vitro) - Celastrol Induces Mitochondria-Mediated Apoptosis in Hepatocellular Carcinoma Bel-7402 Cells Read More: http://www.worldscientific.com/doi/abs/10.1142/S0192415X15500093
Tripterygium_W / Liver / (In Vitro) - Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity
Tripterygium_W / Liver / (In Vitro, In Vivo) - Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo
Tripterygium_W / Liver / (In Vitro, In Vivo) - Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts
Tripterygium_W / Liver / (In Vitro, In Vivo) - Celastrol-mediated growth inhibition of subcutaneously transplanted hepatocarcinoma in nude mice
Tripterygium_W / Liver / (In Vivo) - Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
Tripterygium_W / Brain / (In Vitro, Chemo, Synergy) - Pharmacogenomic Approach Reveals a Role for the xc− Cystine/Glutamate Antiporter in Growth and Celastrol Resistance of Glioma Cell Lines
Tripterygium_W / Brain / (In Vitro) - Celastrol inhibits human glioma xenograft
Tripterygium_W / Brain / (In Vivo) - Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study.
Tripterygium_W / Brain / (In Vitro, In Vivo) - Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
Tripterygium_W / Brain / (In Vivo) - Celastrol Blocks Interleukin-6 Gene Expression via Downregulation of NF-κB in Prostate Carcinoma Cells
Tripterygium_W / Prostate / (In Vitro) - Effect of Celastrol on Growth Inhibition of Prostate Cancer Cells through the Regulation of hERG Channel In Vitro
Tripterygium_W / Prostate / (In Vitro, In Vivo) - Celastrol Induces Autophagy by Targeting AR/miR-101 in Prostate Cancer Cells
Tripterygium_W / Prostate / (In Vitro) - Celastrol Potentiates Radiotherapy by Impairment of DNA Damage Processing in Human Prostate Cancer
Tripterygium_W / Prostate / (In Vitro, In Vivo, Chemo, Synergy) - Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB
Tripterygium_W / Prostate / (In Vitro, In Vivo) - Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer
Tripterygium_W / Prostate / (In Vitro, In Vivo) - Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling
Tripterygium_W / Prostate, Stem_Cell / (In Vitro) - Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
Tripterygium_W / Lung, Prostate, Uterus-Cervix / (In Vitro) - Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study
Tripterygium_W / Bone-Cartilage / (In Vitro, In Vivo) - Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α
Tripterygium_W / Breast / (In Vitro) - Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9
Tripterygium_W / Breast / (In Vitro) - Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol
Tripterygium_W / Breast, Prostate / (In Vitro) - Pharmacologic inhibitors of IκB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo
Tripterygium_W / Bone-Cartilage / (In Vitro, In Vivo) - Synergistic Anti-Cancer Activity by the Combination of TRAIL/APO-2L and Celastrol
Tripterygium_W / Lung, Colon, Ovarian / (In Vitro, In Vivo) - Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
Tripterygium_W / Breast / (In Vitro, In Vivo, Chemo, Synergy) - Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer
Tripterygium_W / Gastric / (In Vitro) - The research of Celastrol on its effect of inducing gastric cancer cell line MGC803 apoptosis
Tripterygium_W / Gastric / (In Vitro) - Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
Tripterygium_W / Gastric / (In Vitro, In Vivo) - A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
Tripterygium_W / Pancreatic / (In Vitro, In Vivo) - Inhibition of Autophagy Strengthens Celastrol-Induced Apoptosis in Human Pancreatic Cancer In Vitro and In Vivo Models
Tripterygium_W / Pancreatic / (In Vitro, In Vivo) - Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells
Tripterygium_W / Bladder / (In Vitro, In Vivo) - Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways
Tripterygium_W / Lung / (In Vitro) - Formulation and Evaluation of Celastrol-Loaded Liposomes
Tripterygium_W / Lung / (In Vivo) - Overcoming cisplatin resistance by celastrol in cancer cells.
Tripterygium_W / Lung / (In Vitro, Chemo, Synergy) - Synergistic Antitumor Activity of Gemcitabine and ABT-737 In Vitro and In Vivo through Disrupting the Interaction of USP9X and Mcl-1
Tripterygium_W / Lung / (In Vitro, In Vivo, Chemo, Synergy) - ATF2 contributes to cisplatin resistance in non-small cell lung cancer and celastrol induces cisplatin resensitization through inhibition of JNK/ATF2 pathway
Tripterygium_W / Lung / (In Vitro, Chemo, Synergy) - Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
Tripterygium_W / Myeloma / (In Vitro, Chemo, Synergy) - NF-Kappa B Modulation Is Involved in Celastrol Induced Human Multiple Myeloma Cell Apoptosis
Tripterygium_W / Myeloma / (In Vitro) - Apoptosis induced by celastrol on multiple cell lines and the effect on cell cycle
Tripterygium_W / Myeloma / (In Vitro) - Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-κB pathway
Tripterygium_W / Myeloma / (In Vitro) - HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
Tripterygium_W / Leukaemia / (In Vitro) - Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol
Tripterygium_W / Leukaemia / (In Vitro) - Inhibition of c-myc by the triterpenoid celastrol
Tripterygium_W / Leukaemia / (In Vitro) - Effects of triptolide on cell proliferation and CXCR4 expression in Burkitt’s lymphoma Raji cells in vitro
Tripterygium_W / Lymphoma / (In Vitro) - Efficacy, pharmacokinetics and tissue distribution of celastrol analogues SBI 064601, SBI 0640599 and SBI 0069272 in C.B-17 SCID mice bearing Daudi Burkitt\\
Tripterygium_W / Lymphoma / (In Vivo) - Celastrol, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation
Tripterygium_W / Leukaemia / (In Vitro, In Vivo) - Celastrol induces unfolded protein response-dependent cell death in head and neck cancer
Tripterygium_W / Head_&_Neck / (In Vitro) - Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer
Tripterygium_W / Lung / (In Vitro, In Vivo) - Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo
Tripterygium_W / Lung, Prostate, Ovarian / (In Vitro, In Vivo, Chemo, Synergy) - Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells
Tripterygium_W / Colon / (In Vitro) - Enhanced anti-tumor activity by the combination of TRAIL/Apo-2L and combretastatin A-4 against human colon cancer cells via induction of apoptosis in vitro and in vivo
Tripterygium_W / Colon / (In Vitro, In Vivo, Chemo, Synergy) - Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling
Tripterygium_W / Melanoma / (In Vitro) - Celastrol Synergistically Enhances Temozolomide Cytotoxicity in Melanoma Cells
Tripterygium_W / Melanoma / (In Vitro, Chemo, Synergy) - Preclinical Studies of Celastrol and Acetyl Isogambogic Acid in Melanoma
Tripterygium_W / Melanoma / (In Vitro, In Vivo) - Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis
Tripterygium_W / Lung, Breast, Prostate, Liver, Uterus-Cervix / (In Vitro) - Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation
Tripterygium_W / Lung / (In Vitro) - Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography–mass spectrometry based metabolic profiling
Tripterygium_W / Uterus-Cervix / (In Vitro) - Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells
Tripterygium_W / Uterus-Cervix, Head_&_Neck / (In Vitro, In Vivo, Chemo, Synergy) - Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance.
Tripterygium_W / Lung / (In Vitro) - Celastrol inhibits high fat diet-induced obesity and intestinal tumorigenesis in APCMin/+ mice by modulating gut microbes and inflammation
Tripterygium_W / Colon, Gastric / (In Vivo) - Celastrol inhibits cancer metastasis by suppressing M2-like polarization of macrophages
Tripterygium_W / Breast / (In Vitro, In Vivo) - Celastrol strongly inhibits proliferation, migration and cancer stem cell properties through suppression of Pin1 in ovarian cancer cells
Tripterygium_W / Ovarian, Stem_Cell / (In Vitro) - Celastrol Binds to HSP90 Trigger Functional Protein Interaction Network Against Pancreatic Cancer
Tripterygium_W / Pancreatic / (In Vitro) - Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis
Tripterygium_W / Colon / (In Vitro) - Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
Tripterygium_W / Ovarian / (In Vitro, In Vivo) - Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species
Tripterygium_W / Lung / (In Vitro, Chemo, Synergy) - Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
Tripterygium_W / Colon / (In Vitro) - Triptolide inhibits the growth and migration of colon carcinoma cells by down-regulation of miR-191
Tripterygium_W / Colon / (In Vitro, In Vivo) - Triptolide suppresses the proliferation and induces the apoptosis of nasopharyngeal carcinoma cells via the PI3K/Akt pathway
Tripterygium_W / Head_&_Neck / (In Vitro) - Triptolide interferes with XRCC1/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin
Tripterygium_W / Breast / (In Vitro, Chemo, Synergy) - Triptolide suppresses growth of breast cancer by targeting HMGB1 in vitro and in vivo
Tripterygium_W / Breast / (In Vitro, In Vivo) - The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer
Tripterygium_W / Lung / (In Vitro) - Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine by inhibiting TLR4/NF-κB signaling
Tripterygium_W / Pancreatic / (In Vitro) - Triptolide reduces proliferation and enhances apoptosis in drug-resistant human oral cancer cells
Tripterygium_W / Oral / (In Vitro) - Celastrol, a plant-derived triterpene, induces cisplatin-resistance nasopharyngeal carcinoma cancer cell apoptosis though ERK1/2 and p38 MAPK signaling pathway
Tripterygium_W / Head_&_Neck / (In Vitro) - Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species
Tripterygium_W / Lung / (In Vitro, Chemo, Synergy) - Celastrol induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity
Tripterygium_W / Myeloma / (In Vitro) - Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells
Tripterygium_W / Lung / (In Vitro, Chemo, Synergy) - Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer
Tripterygium_W / Colon / (In Vitro) - Celastrol Enhances the Anti-Liver Cancer Activity of Sorafenib
Tripterygium_W / Liver / (In Vitro, Chemo, Synergy) - Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway
Tripterygium_W / Brain / (In Vitro, Chemo, Synergy)
