RESEARCHES:

• Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells
  Withaferin_A / Brain / (In Vitro, In Vivo)
• Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis
  Withaferin_A / Brain / (In Vitro, In Vivo)
• Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
  Withaferin_A / Brain / (In Vitro)
• Water Extract of Ashwagandha Leaves Limits Proliferation and Migration, and Induces Differentiation in Glioma Cells
  Withaferin_A / Brain / (In Vitro)
• Withaferin a: a novel therapeutic approach for maligant brain tumors
  Withaferin_A / Brain / (In Vitro)
• The antitumor effects of withaferin a in glioblastoma stem cells
  Withaferin_A / Brain, Stem_Cell / (In Vitro)
• AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models
  Withaferin_A / Brain / (In Vitro, In Vivo)
• Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation
  Withaferin_A / Brain / (In Vitro, Chemo, Synergy)
• Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity
  Withaferin_A / Colon / (In Vitro, In Vivo)
• Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis
  Withaferin_A / Colon / (In Vitro)
• nti-cancer activity of withaferin A in B-cell lymphoma
  Withaferin_A / Lymphoma / (In Vitro, In Vivo)
• Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model
  Withaferin_A / Lymphoma, Stem_Cell / (In Vitro)
• Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells
  Withaferin_A / Pancreatic / (In Vitro, In Vivo, Chemo, Synergy)
• Abstract LB-154: Epigenetic silencing of triple-negative breast cancer hallmarks by Withaferin A
  Withaferin_A / Breast / (In Vitro)
• Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin
  Withaferin_A / Breast / (In Vitro)
• Abstract 3686: Activation of signal transducer and activator of transcription 3 fails to confer resistance against withaferin A-induced apoptosis in human breast cancer cells
  Withaferin_A / Breast / (In Vitro)
• Hyperactivated NF-κB and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells
  Withaferin_A / Breast / (In Vitro)
• Lipopolysaccharides-stimulated macrophage products enhance Withaferin A-induced apoptosis via activation of caspases and inhibition of NF-κB pathway in human cancer cells
  Withaferin_A / Breast, Prostate / (In Vitro)
• Withaferin A inhibits experimental epithelial–mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors
  Withaferin_A / Breast / (In Vitro, In Vivo)
• Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation
  Withaferin_A / Breast / (In Vitro, In Vivo)
• Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo
  Withaferin_A / Breast / (In Vitro, In Vivo)
• Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition
  Withaferin_A / Breast / (In Vitro, In Vivo)
• Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression
  Withaferin_A / Breast / (In Vitro, In Vivo)
• Effect of withaferin a on ehrlich ascites tumor cells — cytological observations†
  Withaferin_A / Breast / (In Vitro, In Vivo)
• Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells
  Withaferin_A / Breast / (In Vitro)
• Effect of withaferin a on Ehrlich ascites tumor cells. II. Target tumor cell destruction in vivo by immune activation
  Withaferin_A / Breast / (In Vitro, In Vivo)
• Metabolic Alterations in Mammary Cancer Prevention by Withaferin A in a Clinically Relevant Mouse Model
  Withaferin_A / Breast / (In Vivo)
• Effect of an Extract of Withania somnifera Root on Estrogen Receptor-positive Mammary Carcinomas
  Withaferin_A / Breast / (In Vitro, In Vivo)
• Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown
  Withaferin_A / Breast / (In Vivo)
• Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo
  Withaferin_A / Breast / (In Vivo)
• Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract
  Withaferin_A / Myeloma / (In Vitro, In Vivo)
• Withaferin A induces cell death and differentiation in multiple myeloma cancer stem cells
  Withaferin_A / Myeloma / (In Vitro)
• Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells
  Withaferin_A / Uterus-Cervix / (In Vitro)
• Withaferin A Suppresses Anti-apoptotic BCL2, Bcl-xL, XIAP and Survivin Genes in Cervical Carcinoma Cells
  Withaferin_A / Uterus-Cervix / (In Vitro)
• Withaferin A Inhibits PMA-Induced MMP-9 Expression in Human Cervical Carcinoma Caski Cells
  Withaferin_A / Uterus-Cervix / (In Vitro)
• Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells
  Withaferin_A / Uterus-Cervix / (In Vitro, In Vivo)
• Selective Killing of Cancer Cells by Leaf Extract of Ashwagandha: Identification of a Tumor-Inhibitory Factor and the First Molecular Insights to Its Effect
  Withaferin_A / Bone-Cartilage / (In Vitro, In Vivo)
• Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling
  Withaferin_A / Bone-Cartilage / (In Vitro)
• Protective role of withaferin-A on 7,12-dimethylbenz(a)anthracene-induced genotoxicity in bone marrow of Syrian golden hamsters
  Withaferin_A / Bone-Cartilage / (In Vivo)
• Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180
  Withaferin_A / Bone-Cartilage / (In Vitro)
• Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
  Withaferin_A / Lung / (In Vitro, In Vivo)
• Withania somnifera Dunal (Ashwagandha):Potential plant source of a promising drug for cancer chemotherapy and radiosensitization
  Withaferin_A / Lung / (In Vitro, Chemo, Synergy)
• Glucose metabolism-targeted therapy and withaferin A are effective for epidermal growth factor receptor tyrosine kinase inhibitor-induced drug-tolerant persisters
  Withaferin_A / Lung / (In Vitro, Chemo, Synergy)
• Withania somnifera Root Extract Has Potent Cytotoxic Effect against Human Malignant Melanoma Cells
  Withaferin_A / Melanoma / (In Vitro)
• In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma
  Withaferin_A / Breast / (In Vivo)
• Chemopreventive activity ofWithania somnifera in experimentally induced fibrosarcoma tumours in Swiss albino mice
  Withaferin_A / Bone-Cartilage / (In Vivo)
• Circadian time-dependent chemopreventive potential of withaferin-A in 7,12-dimethyl-benz[a]anthracene-induced oral carcinogenesis
  Withaferin_A / Oral / (In Vivo)
• Withaferin A synergizes TRAIL-induced apoptosis in human oral cancer cells
  Withaferin_A / Oral / (In Vitro)
• Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters.
  Withaferin_A / Oral, Uterus-Cervix, Head_&_Neck, Bone-Cartilage / (In Vivo)
• Withania somnifera Root Extract Prevents DMBA-Induced Squamous Cell Carcinoma of Skin in Swiss Albino Mice
  Withaferin_A / Skin / (In Vivo)
• The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5β, 6β-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model
  Withaferin_A / Skin / (In Vivo)
• Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice
  Withaferin_A / Skin, Gastric / (In Vivo)
• Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model
  Withaferin_A / Skin / (In Vivo)
• Withaferin A targets heat shock protein 90 in pancreatic cancer cells
  Withaferin_A / Pancreatic / (In Vitro, In Vivo)
• A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo
  Withaferin_A / Thyroidal / (In Vivo)
• Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells
  Withaferin_A / Prostate / (In Vitro)
• Withaferin A, a Steroidal Lactone from Withania somnifera, Induces Mitotic Catastrophe and Growth Arrest in Prostate Cancer Cells
  Withaferin_A / Prostate / (In Vitro)
• Genomic Analysis Highlights the Role of the JAK-STAT Signaling in the Anti-Proliferative Effects of Dietary Flavonoid—‘Ashwagandha’ in Prostate Cancer Cells
  Withaferin_A / Prostate / (In Vitro)
• Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies
  Withaferin_A / Uterus-Cervix, Bone-Cartilage / (In Vitro, In Vivo)
• The Tumor Proteasome Is a Primary Target for the Natural Anticancer Compound Withaferin A Isolated from “Indian Winter Cherry”
  Withaferin_A / Prostate / (In Vitro, In Vivo)
• Chemopreventive and chemotherapeutic effect of Withaferin-A on in vivo models of prostate cancer
  Withaferin_A / Prostate / (In Vivo)
• Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A
  Withaferin_A / Ovarian / (In Vitro)
• Withaferin A Alone and in Combination with Cisplatin Suppresses Growth and Metastasis of Ovarian Cancer by Targeting Putative Cancer Stem Cells
  Withaferin_A / Ovarian, Stem_Cell / (In Vitro, In Vivo)
• Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells
  Withaferin_A / Ovarian, Stem_Cell / (In Vitro)
• Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
  Withaferin_A / Kidney / (In Vitro)
• Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation
  Withaferin_A / Leukaemia / (In Vitro)
• Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
  Withaferin_A / Leukaemia / (In Vitro)
• Withania somnifera Water Extract as a Potential Candidate for Differentiation Based Therapy of Human Neuroblastomas
  Withaferin_A / Neuro / (In Vitro)
• Withaferin A, a Cytotoxic Steroid from Vassobia breviflora, Induces Apoptosis in Human Head and Neck Squamous Cell Carcinoma
  Withaferin_A / Head_&_Neck / (In Vitro)
• Withaferin A induces apoptosis through the generation of thiol oxidation in human head and neck cancer cells
  Withaferin_A / Head_&_Neck / (In Vitro)
• Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell
  Withaferin_A / Stem_Cell / (In Vitro)
• Study on the Anticarcinogenic Efficacy of Withaferin-A in DEN Induced Hepatocellular Carcinoma: Morphology and Histopathology
  Withaferin_A / Liver / (In Vitro, In Vivo)
• Withaferin A Inhibits PMA-Induced MMP-9 Expression in Human Cervical Carcinoma Caski Cells
  Withaferin_A / Uterus-Cervix / (In Vitro)
• Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation
  Withaferin_A / Melanoma, Eye_Cavity / (In Vitro, In Vivo)
• Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines
  Withaferin_A / Ovarian / (In Vitro, Chemo, Synergy)
• Oral administration of withaferin A inhibits carcinogenesis of prostate in TRAMP model
  Withaferin_A / Prostate / (In Vivo)
• Withaferin-A: A Potential Anticancer Withanolide from Withania somnifera (L.) Dun.
  Withaferin_A / Lung, Breast, Uterus-Cervix, Head_&_Neck / (In Vitro, In Vivo)
• Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis
  Withaferin_A / Head_&_Neck / (In Vitro, In Vivo)
• Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells
  Withaferin_A / Colon / (In Vitro)
• Withaferin A and tumor treating fields synergistically inhibit glioma proliferation
  Withaferin_A / Brain / (In Vitro, In Vivo, Chemo, Synergy)
• Withaferin A induces cytoprotective autophagy in hepatocellular cancer cells and concomitant autophagic inhibition augments the efficacy of Withaferin A in hepatocellular carcinoma
  Withaferin_A / Liver / (In Vitro)
• Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms
  Withaferin_A, Sulforaphane / Breast / (Synergy)
• Withaferin A inhibits epithelial-to-mesenchymal transition in non-small lung cell cancer cells via regulation of SMAD and NFkB signaling
  Withaferin_A / Lung / (In Vitro)
• Peptidyl‐prolyl cis/trans isomerase Pin1 regulates withaferin A‐mediated cell cycle arrest in human breast cancer cells
  Withaferin_A / Breast / (In Vitro)
• Chemo prevention effect of Withaferin A, a natural compound, on mouse models of colorectal carcinogenesis
  Withaferin_A / Colon / (In Vivo)
• Withaferin-A: a candidate anti-tumour natural compound for non-small cell lung cancer and stem cells
  Withaferin_A / Lung, Stem_Cell / (In Vitro)
• The chemopreventive effect of withaferin A on spontaneous and inflammation-associated colon carcinogenesis models
  Withaferin_A / Colon / (In Vivo)
• Assessment of the Immune Status in “Withaferin A” Treated Rats in Experimental Mammary Carcinogenesis by Flow Cytometry
  Withaferin_A / Breast / (In Vivo)
• Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells
  Withaferin_A / Breast / (In Vitro, In Vivo)
• https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013536
  Withaferin_A / Breast / (In Vitro)
• Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells
  Withaferin_A / Lung / (In Vitro)
• Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics
  Withaferin_A / Breast / (In Vitro)
• Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
  Withaferin_A / Breast / (In Vitro)