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Research Base – Cancer – Withaferin Athe admin2020-10-02T10:28:43-01:00Withania somnifera (Ashawagandha) is very revered herb of the Indian Ayurvedic system of medicine as a Rasayana (tonic). It is used for various kinds of disease processes and specially as a nervine tonic. Considering these facts many scientific studies were carried out and its adaptogenic / anti-stress activities were studied in detail. In experimental models it increases the stamina of rats during swimming endurance test and prevented adrenal gland changes of ascorbic acid and cortisol content produce by swimming stress. It has a Cognition Promoting Effect and was useful in children with memory deficit and in old age people loss of memory. It was also found useful in neurodegenerative diseases such as Parkinson’s, Huntington’s and Alzeimer’s diseases. It has anxiolytic effect and improves energy levels and mitochondrial health. It is an anti-inflammatory and angiogenesis inhibitory agent and was found useful in clinical cases of Arthritis. It also appears to influence the thyroid, the endocrine, cardiopulmonary and central nervous systems. Toxicity studies reveal that W. somnifera can be used without side effects.
Withaferin A is an important phytoconstituents of Withania somnifera (W. Somnifera) belonging to the category of withanolides, that are a group of naturally occurring C28–steroidal lactone triterpenoids. Withaferin A has been used in the traditional and indigenous system of medicine for the treatment of various disorders. In view of its unique therapeutic potential, it has gained much attention in the modern science. In the couple of the years, Withaferin A has been scientifically validated for different pharmacological activities including anti–cancer, adaptogenic, anti–stress, anti–convulsant, immunomodulatory, neurological, anti–inflammatory, anti–tumor, cardioprotective, and neuroprotective activities. Withaferin A has a very impressive pharmacological profile especially against cancer and could be useful for the treatment of cancer and other metabolic disorders.
Pharmacological and analytical aspects of Withaferin A are presented in the articles below.
RESEARCHES:
- Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells
Withaferin_A / Brain / (In Vitro, In Vivo) - Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis
Withaferin_A / Brain / (In Vitro, In Vivo) - Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
Withaferin_A / Brain / (In Vitro) - Water Extract of Ashwagandha Leaves Limits Proliferation and Migration, and Induces Differentiation in Glioma Cells
Withaferin_A / Brain / (In Vitro) - Withaferin a: a novel therapeutic approach for maligant brain tumors
Withaferin_A / Brain / (In Vitro) - The antitumor effects of withaferin a in glioblastoma stem cells
Withaferin_A / Brain, Stem_Cell / (In Vitro) - AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models
Withaferin_A / Brain / (In Vitro, In Vivo) - Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation
Withaferin_A / Brain / (In Vitro, Chemo, Synergy) - Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity
Withaferin_A / Colon / (In Vitro, In Vivo) - Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis
Withaferin_A / Colon / (In Vitro) - nti-cancer activity of withaferin A in B-cell lymphoma
Withaferin_A / Lymphoma / (In Vitro, In Vivo) - Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model
Withaferin_A / Lymphoma, Stem_Cell / (In Vitro) - Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells
Withaferin_A / Pancreatic / (In Vitro, In Vivo, Chemo, Synergy) - Abstract LB-154: Epigenetic silencing of triple-negative breast cancer hallmarks by Withaferin A
Withaferin_A / Breast / (In Vitro) - Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin
Withaferin_A / Breast / (In Vitro) - Abstract 3686: Activation of signal transducer and activator of transcription 3 fails to confer resistance against withaferin A-induced apoptosis in human breast cancer cells
Withaferin_A / Breast / (In Vitro) - Hyperactivated NF-κB and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells
Withaferin_A / Breast / (In Vitro) - Lipopolysaccharides-stimulated macrophage products enhance Withaferin A-induced apoptosis via activation of caspases and inhibition of NF-κB pathway in human cancer cells
Withaferin_A / Breast, Prostate / (In Vitro) - Withaferin A inhibits experimental epithelial–mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors
Withaferin_A / Breast / (In Vitro, In Vivo) - Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation
Withaferin_A / Breast / (In Vitro, In Vivo) - Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo
Withaferin_A / Breast / (In Vitro, In Vivo) - Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition
Withaferin_A / Breast / (In Vitro, In Vivo) - Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression
Withaferin_A / Breast / (In Vitro, In Vivo) - Effect of withaferin a on ehrlich ascites tumor cells — cytological observations†
Withaferin_A / Breast / (In Vitro, In Vivo) - Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells
Withaferin_A / Breast / (In Vitro) - Effect of withaferin a on Ehrlich ascites tumor cells. II. Target tumor cell destruction in vivo by immune activation
Withaferin_A / Breast / (In Vitro, In Vivo) - Metabolic Alterations in Mammary Cancer Prevention by Withaferin A in a Clinically Relevant Mouse Model
Withaferin_A / Breast / (In Vivo) - Effect of an Extract of Withania somnifera Root on Estrogen Receptor-positive Mammary Carcinomas
Withaferin_A / Breast / (In Vitro, In Vivo) - Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown
Withaferin_A / Breast / (In Vivo) - Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo
Withaferin_A / Breast / (In Vivo) - Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract
Withaferin_A / Myeloma / (In Vitro, In Vivo) - Withaferin A induces cell death and differentiation in multiple myeloma cancer stem cells
Withaferin_A / Myeloma / (In Vitro) - Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells
Withaferin_A / Uterus-Cervix / (In Vitro) - Withaferin A Suppresses Anti-apoptotic BCL2, Bcl-xL, XIAP and Survivin Genes in Cervical Carcinoma Cells
Withaferin_A / Uterus-Cervix / (In Vitro) - Withaferin A Inhibits PMA-Induced MMP-9 Expression in Human Cervical Carcinoma Caski Cells
Withaferin_A / Uterus-Cervix / (In Vitro) - Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells
Withaferin_A / Uterus-Cervix / (In Vitro, In Vivo) - Selective Killing of Cancer Cells by Leaf Extract of Ashwagandha: Identification of a Tumor-Inhibitory Factor and the First Molecular Insights to Its Effect
Withaferin_A / Bone-Cartilage / (In Vitro, In Vivo) - Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling
Withaferin_A / Bone-Cartilage / (In Vitro) - Protective role of withaferin-A on 7,12-dimethylbenz(a)anthracene-induced genotoxicity in bone marrow of Syrian golden hamsters
Withaferin_A / Bone-Cartilage / (In Vivo) - Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180
Withaferin_A / Bone-Cartilage / (In Vitro) - Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
Withaferin_A / Lung / (In Vitro, In Vivo) - Withania somnifera Dunal (Ashwagandha):Potential plant source of a promising drug for cancer chemotherapy and radiosensitization
Withaferin_A / Lung / (In Vitro, Chemo, Synergy) - Glucose metabolism-targeted therapy and withaferin A are effective for epidermal growth factor receptor tyrosine kinase inhibitor-induced drug-tolerant persisters
Withaferin_A / Lung / (In Vitro, Chemo, Synergy) - Withania somnifera Root Extract Has Potent Cytotoxic Effect against Human Malignant Melanoma Cells
Withaferin_A / Melanoma / (In Vitro) - In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma
Withaferin_A / Breast / (In Vivo) - Chemopreventive activity ofWithania somnifera in experimentally induced fibrosarcoma tumours in Swiss albino mice
Withaferin_A / Bone-Cartilage / (In Vivo) - Circadian time-dependent chemopreventive potential of withaferin-A in 7,12-dimethyl-benz[a]anthracene-induced oral carcinogenesis
Withaferin_A / Oral / (In Vivo) - Withaferin A synergizes TRAIL-induced apoptosis in human oral cancer cells
Withaferin_A / Oral / (In Vitro) - Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters.
Withaferin_A / Oral, Uterus-Cervix, Head_&_Neck, Bone-Cartilage / (In Vivo) - Withania somnifera Root Extract Prevents DMBA-Induced Squamous Cell Carcinoma of Skin in Swiss Albino Mice
Withaferin_A / Skin / (In Vivo) - The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5β, 6β-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model
Withaferin_A / Skin / (In Vivo) - Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice
Withaferin_A / Skin, Gastric / (In Vivo) - Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model
Withaferin_A / Skin / (In Vivo) - Withaferin A targets heat shock protein 90 in pancreatic cancer cells
Withaferin_A / Pancreatic / (In Vitro, In Vivo) - A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo
Withaferin_A / Thyroidal / (In Vivo) - Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells
Withaferin_A / Prostate / (In Vitro) - Withaferin A, a Steroidal Lactone from Withania somnifera, Induces Mitotic Catastrophe and Growth Arrest in Prostate Cancer Cells
Withaferin_A / Prostate / (In Vitro) - Genomic Analysis Highlights the Role of the JAK-STAT Signaling in the Anti-Proliferative Effects of Dietary Flavonoid—‘Ashwagandha’ in Prostate Cancer Cells
Withaferin_A / Prostate / (In Vitro) - Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies
Withaferin_A / Uterus-Cervix, Bone-Cartilage / (In Vitro, In Vivo) - The Tumor Proteasome Is a Primary Target for the Natural Anticancer Compound Withaferin A Isolated from “Indian Winter Cherry”
Withaferin_A / Prostate / (In Vitro, In Vivo) - Chemopreventive and chemotherapeutic effect of Withaferin-A on in vivo models of prostate cancer
Withaferin_A / Prostate / (In Vivo) - Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A
Withaferin_A / Ovarian / (In Vitro) - Withaferin A Alone and in Combination with Cisplatin Suppresses Growth and Metastasis of Ovarian Cancer by Targeting Putative Cancer Stem Cells
Withaferin_A / Ovarian, Stem_Cell / (In Vitro, In Vivo) - Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells
Withaferin_A / Ovarian, Stem_Cell / (In Vitro) - Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
Withaferin_A / Kidney / (In Vitro) - Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation
Withaferin_A / Leukaemia / (In Vitro) - Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
Withaferin_A / Leukaemia / (In Vitro) - Withania somnifera Water Extract as a Potential Candidate for Differentiation Based Therapy of Human Neuroblastomas
Withaferin_A / Neuro / (In Vitro) - Withaferin A, a Cytotoxic Steroid from Vassobia breviflora, Induces Apoptosis in Human Head and Neck Squamous Cell Carcinoma
Withaferin_A / Head_&_Neck / (In Vitro) - Withaferin A induces apoptosis through the generation of thiol oxidation in human head and neck cancer cells
Withaferin_A / Head_&_Neck / (In Vitro) - Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell
Withaferin_A / Stem_Cell / (In Vitro) - Study on the Anticarcinogenic Efficacy of Withaferin-A in DEN Induced Hepatocellular Carcinoma: Morphology and Histopathology
Withaferin_A / Liver / (In Vitro, In Vivo) - Withaferin A Inhibits PMA-Induced MMP-9 Expression in Human Cervical Carcinoma Caski Cells
Withaferin_A / Uterus-Cervix / (In Vitro) - Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation
Withaferin_A / Melanoma, Eye_Cavity / (In Vitro, In Vivo) - Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines
Withaferin_A / Ovarian / (In Vitro, Chemo, Synergy) - Oral administration of withaferin A inhibits carcinogenesis of prostate in TRAMP model
Withaferin_A / Prostate / (In Vivo) - Withaferin-A: A Potential Anticancer Withanolide from Withania somnifera (L.) Dun.
Withaferin_A / Lung, Breast, Uterus-Cervix, Head_&_Neck / (In Vitro, In Vivo) - Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis
Withaferin_A / Head_&_Neck / (In Vitro, In Vivo) - Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells
Withaferin_A / Colon / (In Vitro) - Withaferin A and tumor treating fields synergistically inhibit glioma proliferation
Withaferin_A / Brain / (In Vitro, In Vivo, Chemo, Synergy) - Withaferin A induces cytoprotective autophagy in hepatocellular cancer cells and concomitant autophagic inhibition augments the efficacy of Withaferin A in hepatocellular carcinoma
Withaferin_A / Liver / (In Vitro) - Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms
Withaferin_A, Sulforaphane / Breast / (Synergy) - Withaferin A inhibits epithelial-to-mesenchymal transition in non-small lung cell cancer cells via regulation of SMAD and NFkB signaling
Withaferin_A / Lung / (In Vitro) - Peptidyl‐prolyl cis/trans isomerase Pin1 regulates withaferin A‐mediated cell cycle arrest in human breast cancer cells
Withaferin_A / Breast / (In Vitro) - Chemo prevention effect of Withaferin A, a natural compound, on mouse models of colorectal carcinogenesis
Withaferin_A / Colon / (In Vivo) - Withaferin-A: a candidate anti-tumour natural compound for non-small cell lung cancer and stem cells
Withaferin_A / Lung, Stem_Cell / (In Vitro) - The chemopreventive effect of withaferin A on spontaneous and inflammation-associated colon carcinogenesis models
Withaferin_A / Colon / (In Vivo) - Assessment of the Immune Status in “Withaferin A” Treated Rats in Experimental Mammary Carcinogenesis by Flow Cytometry
Withaferin_A / Breast / (In Vivo) - Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells
Withaferin_A / Breast / (In Vitro, In Vivo) - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013536
Withaferin_A / Breast / (In Vitro) - Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells
Withaferin_A / Lung / (In Vitro) - Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics
Withaferin_A / Breast / (In Vitro) - Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
Withaferin_A / Breast / (In Vitro)
