Withania somnifera (Ashawagandha) is very revered herb of the Indian Ayurvedic system of medicine as a Rasayana (tonic). It is used for various kinds of disease processes and specially as a nervine tonic. Considering these facts many scientific studies were carried out and its adaptogenic / anti-stress activities were studied in detail. In experimental models it increases the stamina of rats during swimming endurance test and prevented adrenal gland changes of ascorbic acid and cortisol content produce by swimming stress.  It has a Cognition Promoting Effect and was useful in children with memory deficit and in old age people loss of memory. It was also found useful in neurodegenerative diseases such as Parkinson’s, Huntington’s and Alzeimer’s diseases. It has anxiolytic effect and improves energy levels and mitochondrial health. It is an anti-inflammatory and angiogenesis inhibitory agent and was found useful in clinical cases of ArthritisIt also appears to influence the thyroid, the endocrine, cardiopulmonary and central nervous systems. Toxicity studies reveal that Wsomnifera can be used without side effects.
Withaferin A is an important phytoconstituents of Withania somnifera (W. Somnifera) belonging to the category of withanolides, that are a group of naturally occurring C28–steroidal lactone triterpenoids. Withaferin A has been used in the traditional and indigenous system of medicine for the treatment of various disorders. In view of its unique therapeutic potential, it has gained much attention in the modern science. In the couple of the years, Withaferin A has been scientifically validated for different pharmacological activities including anti–cancer, adaptogenic, anti–stress, anti–convulsant, immunomodulatory, neurological, anti–inflammatory, anti–tumor, cardioprotective, and neuroprotective activities.  Withaferin A has a very impressive pharmacological profile especially against cancer and could be useful for the treatment of cancer and other metabolic disorders.
Pharmacological and analytical aspects of Withaferin A are presented in the articles below.

 

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